Skip to main content

This job has expired

PhD Studentship: Dissecting the molecular pathways linking ribosome biogenesis, the nucleolar stres

Employer
Global Academy Jobs
Location
United Kingdom
Closing date
Feb 28, 2018

Job Details

Details

Ribosome biogenesis is inextricably linked to cell growth and proliferation and uncontrolled cell growth is associated with increased levels of ribosome biogenesis. Further, It is emerging that the site of ribosome assembly, the nucleolus, acts as a key stress sensor, where many cellular stresses converge and act to trigger p53 stabilization resulting in growth arrest, apoptosis or cellular senescence. Multiple studies have suggested a link between ribosome biogenesis, cell transformation and the nucleolar stress response. However, the molecular mechanisms linking and regulating these processes remains largely uncharacterized. One factor that appears to connect these pathways is GLTSCR2 which has been shown to be directly involved in ribosome biogenesis and the nucleolar stress response. This project will investigate the overlapping roles that GLTSCR2 plays by dissecting the molecular interactions within each process to allow its disruption within one pathway, effectively uncoupling it from the other. This will be achieved using a combination of molecular biology techniques and subsequent in vivo analysis in embryonic stem cells.

 

Eligibility:

The successful candidate will join a young and dynamic lab located within the highly collaborative environment of the Molecular biology and biotechnology department at the University of Sheffield. Candidates are expected to have, or about to obtain, an upper second class undergraduate degree in molecular biology, biochemistry or a related subject area. A Masters qualification in a similar area and relevant practical experience would be a distinct advantage.

 

Funding Notes

  • Full tuition fees (UK and EU).
  • Annual, tax-free maintenance stipend at the standard RCUK rate (2016/17 is £14,296).
  • Research Training Support Grant to cover international travel, secondments and exchanges.

 

These scholarships fund up to 3.5 years full-time study, subject to satisfactory progress.

Company

Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."

Company info
Website

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert