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PhD student FHML/School for Cardiovascular Diseases/CARIM-Physiology

Employer
Global Academy Jobs
Location
Netherlands
Closing date
Jun 29, 2016

Job Details

Open PhD position/Early Stage Researcher in the field of atrial electrophysiology and computational approaches to atrial arrhythmias

Solliciteer binnen 12 dagen op deze vacature

Job Description

The Dept. of Physiology offers a PhD position/Early Stage Researcher in the field of atrial electrophysiology and computational cardiology to establish a 3D model of AF progression using a combined animal experiment and computational modeling approach. The position is associated to AFib-TrainNet funded from the Marie Skłodowska-Curie Actions as a European Training Network (ETN).

The project aims at the development of a combined experimental and computational model to study 3D structure-function interaction of AF complexity as a mechanism causing AF progression. The model will be used and validated for predicting antiarrhythmic action of novel drugs at different stages of AF as a tool for more efficient drug discovery. The PhD candidate will be trained in advanced electrical mapping (simultaneous endo-and epicardial high density mapping) and imaging techniques (high resolution MRI) to correlate 3D patterns of fibrillation waves to complex atrial bundle architecture. The experimental data will be generated at different stages of AF in a well-established goat model of progressive electrical and structural atrial remodeling, and will be implemented into a 3D computer model of AF in collaboration with project partners at Simula Research Laboratory and Center for Computational Modeling in Cardiology (CCMC). The model will be tested for predicting the antiarrhythmic potential of new calcium- and acetylcholine activated K+ channel blockers at different stages of AF progression and validated in the AF goat model by drug testing experiments.

Requirements

The candidate holds a master in biology, medicine, biochemistry, pharmacology, biomedical engineering, or related disciplines. At the time of recruitment, the candidate must not have resided or carried out their main activity in the country of their host beneficiary for more than 12 months in the past 3 years. Excellent English skills are a prerequisite for this position. Previous experience with programming (Matlab), or experimental techniques in cardiac electrophysiology is considered a plus.

Conditions

The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website www.maastrichtuniversity.nl, employees, A-Z.

Temporary employment for 3 years.

Your salary would be € 2.174,- gross per month in the first year up to € 2.779,- gross per month in the fourth year according to the PhD-student salary scale.

Each year an evaluation will take place.

Employment

Temporary, 3 years

Organisation

http://www.maastrichtuniversity.nl/

Maastricht University is renowned for its unique, innovative, problem-based learning system, which is characterized by a small-scale and student-oriented approach. Research at UM is characterized by a multidisciplinary and thematic approach, and is concentrated in research institutes and schools. Maastricht University has around 16,000 students and 4,000 employees. Reflecting the university's strong international profile, a fair amount of both students and staff are from abroad. The university hosts 6 faculties: Faculty of Health, Medicine and Life Sciences, Faculty of Law, School of Business and Economics, Faculty of Humanities and Sciences, Faculty of Arts and Social Sciences, Faculty of Psychology and Neuroscience.

Department

CARIM - School for Cardiovascular Diseases

CARIM  - School for Cardiovascular Diseases

The Cardiovascular Research Institute Maastricht (CARIM), School for Cardiovascular Diseases, is one of the top institutes for translational cardiovascular research in Europe. It is among the world leaders in the fields of research into vascular and thrombotic disorders and atrial fibrillation as well as translational heart failure research. It has also made important international contributions to molecular imaging in the cardiovascular field.

With an annual budget of approximately 22,000,000 Euros in 2014, CARIM is one of the largest cardiovascular research institutes in Europe, producing more than 550 scientific articles and approximately 30 PhD dissertations per year. CARIM employs 250 researchers from 13 disciplines, about 120 PhD students and 50 technical and support staff members.

Over the last ten years, CARIM papers have been published in high-impact journals such as the New England Journal of Medicine, JAMA, Nature Medicine, Nature Cell Biology, Cell Metabolism, Journal of Experimental Medicine, Circulation, Lancet Neurology, and the Journal of the American College of Cardiology. Bibliometric analyses illustrate that CARIM publications have been cited 1.97 times more often than the world average for the cardiovascular field in the period of 2009 until 2012.

CARIM is recognized by the KNAW as a research school and as an international training site for Early Stage Researchers in the framework of the Marie Curie Program.

Cardiovascular scientists from around the world join CARIM because it values open communication, close cooperation, high ambitions, good facilities and a critical learning environment.

Additional Information

Prof U. Schotten, dept Physiology schotten@maastrichtuniversity.nl

This PhD scholarship is an integrated part of AFib-TrainNet (afib.ku.dk/). This doctoral training network consists of top European institutions and highly specialized biotech companies with the complementary competences needed to produce both outstanding research results and an excellent training environment for early stage researchers (ESRs). In the Network, 15 ESRs from the partner institutions will enroll simultaneously, and together benefit from an extensive web of training events. AFib-TrainNet also features a number of longer secondment periods to partners within the Network. This coordinated research exchange reflects our focus on top-level interdisciplinary science, and ensures that ESRs have the opportunity to forge strong relationships cross-network and reap the benefits of the world-class, highly interdisciplinary team of collaborating partners

The project will be primarily located at the Dept of Physiology, Maastricht University, The Netherlands, and embedded in CARIM School for Cardiovascular diseases. CARIM combines high-level scientific research with high-level education of young researchers and is therefore recognized as an international training site for Early Stage Researchers by the European Union (www.carimmaastricht.nl). The program on Experimental Atrial Fibrillation (principle investigator Ulrich Schotten) spans the translational axis from biochemistry and subcellular compartmentation to implementation of treatment in AF patients using a multidisciplinary approach of genetics, cellular electrophysiology, microscopic and macroscopic imaging, computational modeling, and clinical electrophysiology. The project includes secondments at Simula Research Laboratory, Oslo, Norway and/or CCMC, Lugano, Switzerland for the implementation of experimental large animal data on atrial electrophysiology and structure into a 3D computational model.

Company

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