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Research Fellow in Single Molecule Biophsyics

Employer
Global Academy Jobs
Location
United Kingdom
Closing date
Jul 29, 2016

Job Details

Project Title: Deciphering the allosteric mechanism of protein translocation through membranes

You are invited to join and interdisciplinary BBSRC-funded project which aims to understand the molecular basis of protein translocation across biological membranes which is mediated by the SecYEG-SecA complex. The project is part of an on-going collaboration between the groups of Dr. Roman Tuma and Prof. Sheena Radford at the University of Leeds and Prof. Ian Collinson at the University of Bristol. A recent joint publication, (Allen, W, Corey, R, Oatley, P, Sessions, R, Baldwin, SA, Radford, SE, Tuma, R & Collinson, I, 2016, ‘Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation’.eLife) illustrates the breath and power of the interdisciplinary approach at dissecting the mechanism of this complex, multisubunit molecular machine. Your role will be primarily in application and development of novel single molecule fluorescence methods together with computational modelling but it will also require performing established biochemical and biophysical assays.
 
You should have a PhD (or be close to completion) in Biophysics or Biochemistry or a closely allied discipline (e.g. Physics, Chemistry or Optical Engineering). A strong background in fluorescence spectroscopy and methods development and application of single molecule approaches to probe protein dynamics is essential. You should also have experience of handling biological samples, together with the ability to work both independently and also as part of a larger interdisciplinary team.

Informal enquiries may be made to Dr Roman Tuma, tel. +44 (0)113 343 3080, email r.tuma@leeds.ac.uk or to Prof. Sheena Radford, tel. +44 (0)113 343 3170, email s.e.radford@leeds.ac.uk

Click here for further information about working at the University of Leeds www.leeds.ac.uk/info/20025/university_jobs 

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