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Research Fellow: genome stability

Employer
Global Academy Jobs
Location
United Kingdom
Closing date
Sep 5, 2016

Job Details

JOB PURPOSE:

To join the DNA Damage Response Group within the Centre for Cancer Research and Cell Biology led by Dr. Kienan Savage to address pioneering questions at the interface of cell cycle regulation, DNA repair and genome integrity control and its link with cancer development, progression and response to therapy. The project concerns the identification and functional characterisation of novel factors involved in maintaining genome stability and elucidating the essential functions of these proteins with an emphasis on their role in cancer development, progression and/or treatment.

 

MAJOR DUTIES:

  • To design, develop and execute experiments related to the above titled project under the supervision of Dr Kienan Savage, in
  • order to obtain reliable data, then evaluate and interpret the results using methodologies and techniques appropriate to the area
  • of the research.
  • To regularly present results to the research group as part of routine peer review.
  • Initiate and maintain collaborative links with various project partners.
  • To write up results in a timely manner and take a leadership role in writing research manuscripts.
  • To present regular progress reports on research to members of the research group and to external audiences to disseminate
  • and publicise research findings.
  • To formulate, write and submit grants for fellowship awards, project and travel support.
  • To attend and present new experimental data at national and international meetings.
  • May be required to occasionally supervise undergraduate or summer students on mini-projects, within the post holder’s area of
  • expertise and under the direct guidance of a member of academic staff, which will help develop their own supervisory skills.
  • Assist with the supervision of postgraduate students under the direct guidance of a member of academic staff, which will help
  • develop their own supervisory skills. Carry out routine administrative tasks associated with the research project/s to ensure that project/s are completed on time and within budget. These might include organisation of project meetings and documentation, financial control, risk assessment of
  • research activities. 1 Assist grant holder in the preparation of funding proposals and applications to external bodies.
  • Read academic papers, journals and textbooks to keep abreast of developments in own specialism and related disciplines.
  • Any other reasonable duties within the general ambit of the post and competence of post holder.

 

Planning and Organising:

  • Plan for specific aspects of research programmes. Timescales range from 1-6 months in advance and contribute to research group planning.
  • Plan for the use of research resources, laboratories and workshops where appropriate.
  • Plan own day-to day activity within framework of the agreed research programme.
  • Plan up to a year in advance to meet deadlines for journal publications and to prepare presentations and papers for
  • conferences.
  • Coordinate and liaise with other members of the research group over work progress.

 

Resource Management Responsibilities:

  • Ensure research resources are used in an effective and efficient manner.
  • Support the development and training of support staff and students by making their research experience and expertise available.
  • Take shared responsibility for the upkeep of lab equipment and replenishment of lab stocks and exercise due diligence when using equipment.

 

 

 

 

 

Internal and External Relationships:

  • Liaise on a regular basis with colleagues and students.
  • Build internal contacts and participate in internal networks for the exchange of information and to form relationships for future collaboration.
  • Contribute to the School’s outreach programme by establishing links with local community groups, industries etc.
  • Join national and international scientifically relevant societies.

 

 

ESSENTIAL CRITERIA:

  • Must have or be about to obtain a PhD in biochemistry, molecular oncology or molecular/cell biology.
  • At least three years recent relevant experience of high quality molecular oncology or molecular/cell biology in the field of cancer biology, cancer genetics and/or DNA damage response/repair.
  • Experience with human cell culture.
  • Recent experience with molecular biology techniques, to include at least four of the following: PCR/cloning, RNA interference (siRNA/shRNA mediated knockdowns), immunoblotting/Western Blotting, qPCR, immunoprecipitation, generation of stable cell lines, reporter gene assays, cell death and cell viability assays, proliferation assays, immunocytochemistry, fluorescence microscopy, and/or next generation sequencing.
  • Publication record commensurate with research experience.
  • Sufficient breadth and depth of specialist knowledge in the discipline and of research methods and techniques to work within established research programmes.
  • Evidence of communication and networking skills.
  • Track record of extra-mural research presentations.
  • Must have clear and well developed presentation skills.
  • Ability to communicate complex information clearly.
  • Ability to build contacts and participate in internal and external networks.
  • Team worker, highly motivated, supportive of colleagues within the group.
  • Demonstrable intellectual ability.
  • Ability to assess and organise resources.
  • Must be willing to engage with the public and supporting research supporting charities in order to disseminate research findings. 1st Class undergraduate degree in science or pharmacy. Scientific memberships eg. AACR Experience in cancer biology and DNA damage response/repair biology.
  • Use of viral delivery systems for gene and shRNA expression.
  • Experience using in vivo models of cancer.
  • Experience with DNA repair assays.
  • Have published (or be in press) first authored paper(s) in quality journals commensurate with career experience.
  • Experience with high throughput cell based screening assays e.g. siRNA/shRNA screens, drug screen etc.
  • Experience with liquid handling systems and other robotics systems for use with high-throughput assays.

 

 

 

 

DESIRABLE CRITERIA:

  • Experience with high-content Microscopy.
  • Track record of national/international collaboration.
  • Evidence of scientific writing skills.
  • Evidence of past public engagement activities.

 

 

 

 

 

 

Company

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