Junior research fellow FHML; dept Pathology FHML/School for Cardiovascular Diseases/CARIM
Junior research fellow Dept. of Pathology, MUMC+ on chronic kidney disease and microvascular pathology Full time research position for 2 years at the Dept. of Pathology embedded in a collaborative program with the Dept. of Internal Medicine at the Maastricht University Medical Center +.
Job Specifications - (uitleg)
A position for a researcher for two years is available in the Pathology Dept. of Maastricht University Medical Center, on a collaborative project with the department of Internal medicine (Prof. Dr. J. Kooman, Dr. M. Christiaans). The group is embedded in the Cardiovascular Research Institute Maatricht (CARIM), as well as NUTRIM School for Nutrition, Toxicology and Metabolism of the Maastricht University Medical Center+.
Chronic kidney disease (CKD) develops in 10-12% of the Western population and is an independent risk factor for the development of cardiovascular morbidity and mortality. Development of chronic renal failure is multifactorial, with renal fibrosis and inflammation as most prominent features. We recently were the first to show that capillary loss occurs in a very early stage of development of renal fibrosis and precedes renal function loss after transplantation (Steegh et al. J Am Soc Nephrol 2011). The aim of the current project is to study capillary number in renal tissue of patients with or without CKD and thus investigate early disease stages. Renal tissue will be studied with state of the art techniques in relation to clinical parameters but also with systemic capillary function. Furthermore, you will be involved in unravelling the pathofysiological significance of capillary loss for chronic organ dysfunction using animal models and in vitro systems. Using this approach you will be able to translate findings at the bench back to the patient, and also bed-side findings back to the bench. Your work will result in publications in scientific journals.
This research project is an excellent preparation for a residency in pathology, internal medicine or surgery.
Applicants should have a degree in Medicine, Health Sciences or Biology. Individuals with prior experience in translational research are encouraged to apply. You should display great team spirit, perseverance, a driven, independent and curious nature, and excellent verbal and written communication skills in English.
The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website www.maastrichtuniversity.nl > Support > UM employees.
Temporary, 2 years
Maastricht University is renowned for its unique, innovative, problem-based learning system, which is characterized by a small-scale and student-oriented approach. Research at UM is characterized by a multidisciplinary and thematic approach, and is concentrated in research institutes and schools. Maastricht University has around 16,000 students and 4,000 employees. Reflecting the university's strong international profile, a fair amount of both students and staff are from abroad. The university hosts 6 faculties: Faculty of Health, Medicine and Life Sciences, Faculty of Law, School of Business and Economics, Faculty of Humanities and Sciences, Faculty of Arts and Social Sciences, Faculty of Psychology and Neuroscience.
The Cardiovascular Research Institute Maastricht (CARIM), School for Cardiovascular Diseases, is one of the top institutes for translational cardiovascular research in Europe. It is among the world leaders in the fields of research into vascular and thrombotic disorders and atrial fibrillation as well as translational heart failure research. It has also made important international contributions to molecular imaging in the cardiovascular field.
With an annual budget of approximately 22,000,000 Euros in 2015, CARIM is one of the largest cardiovascular research institutes in Europe, producing more than 550 scientific articles and approximately 30 PhD dissertations per year. CARIM employs 250 researchers from 13 disciplines, about 120 PhD students and 50 technical and support staff members.
Over the last ten years, CARIM papers have been published in high-impact journals such as the New England Journal of Medicine, JAMA, Nature Medicine, Nature Cell Biology, Cell Metabolism, Journal of Experimental Medicine, Circulation, Lancet Neurology, and the Journal of the American College of Cardiology. Bibliometric analyses illustrate that CARIM publications have been cited 1.97 times more often than the world average for the cardiovascular field in the period of 2009 until 2012.
CARIM is recognized by the KNAW as a research school and as an international training site for Early Stage Researchers in the framework of the Marie Curie Program.
Cardiovascular scientists from around the world join CARIM because it values open communication, close cooperation, high ambitions, good facilities and a critical learning environment.
For additional information you may contact Dr. C.J. Peutz-Kootstra (firstname.lastname@example.org) or Prof. Dr. E. Biessen (email@example.com); +31 4376620.
Applicants should send their curriculum vitae, a motivated application letter including contact information of two references to firstname.lastname@example.org.