Sr. Scientist, Target & Pathway Biology – Assay Development Job

Sr. Scientist, Target & Pathway Biology – Assay Development-BIO004648


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

We are seeking an experienced laboratory scientist with expertise in assay development and an understanding of human genetics to join the Target and Pathway Biology group within the department of Genetics & Pharmacogenomics (GpGx) at MRL Boston. Our mission in GpGx is to leverage human genetics and cutting edge molecular biology technologies to identify and functionally validate novel targets and pathways for therapeutic intervention. The successful candidate will serve as a hands-on experimentalist responsible for implementing studies that inform on new drug targets and disease-relevant pathways.

The primary responsibilities of the candidate will include:

- Development of medium to high throughput cell-phenotypic and biochemical assays for proof-of-concept functional studies, target validation and compound screening
- Validation of hit compounds for follow-up mechanistic studies and lead-optimization
- Independent leadership of projects with minimal supervision
- Maintaining broad knowledge of literature and state-of-the-art technology
- Witten and verbal communication of study plans and results to project lead and more broadly at team and departmental levels
- Interface broadly with GpGx scientists, Discovery, and Preclinical Pharmacology teams

Expertise in development and implementation of in vitro preclinical assays for support of genetic or compound screening, and good understanding of human genetics are essential. Other requirements include a broad knowledge of disease area biology and experience in using technologies including CRISPR genome editing, RNAi and reporter cell line generation.



- B.S. degree with a minimum of 8 years or M.S. degree with a minimum of 6 years of experience in industry, preferably in genomics, cell biology, molecular biology, biochemistry or a related field, or a Ph.D. with 2+ years of industry experience.


- Deep understanding of and hands-on experience working on development and implementation of cellular and/or biochemical assays for support of genetic or compound screening
- Experience in establishing and working with human and murine in vitro and ex vivo cellular models (iPSC, mammalian immortalized and primary cells)
- Direct experience in development of immunoassay or high content imaging assays on multiple platforms such as MesoScale, Luminex, Opera etc.
- Experience in, or aptitude for, technologies including CRISPR genome editing, RNAi and reporter cell line generation
- Understanding of disease area biology including cardiometabolic, immunology, or neuroscience
- Strong communication, collaboration, and leadership skills, including an ability to communicate experimental design, results and conclusions in a clear and concise manner to biologists, chemists, and senior management
- Other requirements include strong data analysis skills, and high level of flexibility to thrive in a dynamic environment


- Good understanding of human genetics and its application to inform assay and preclinical model development for novel gene discovery
- Experience in communication with vendors and CROs
- Experience in Flow Cytometry and FACS sorting
- Understanding of genomic technologies including NGS, RNAseq, and proteomics approaches
- Experience working with 3D cultures
- A track record of independent critical thinking and scientific achievement in more than one area of research, exemplified by a good publication record

Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at

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Job: Biology-Discovery

Job Title:Sr. Scientist, Biology-Discovery

Primary Location: NA-US-MA-Boston

Employee Status: Regular

Travel: Yes, 5 % of the Time

Number of Openings: 1

Shift (if applicable): 1st

Hazardous Materials: Biological and chemical hazardous agents

Company Trade Name:Merck