Research Fellow

Job Purpose The post-holder will work within the groups of Profs Adam Cunningham and Steve Watson with specific responsibility for delivering the aims and objectives of the MRC funded project entitled: “How does inflammation regulate CLEC-2-mediated thrombosis after infection?”

The focus of the project will be to understand how we can understand and exploit a novel mechanism of thrombosis that we have identified after infection of mice with Salmonella. In this situation, platelets in the blood become activated via CLEC-2. We wish to identify how thrombosis can be beneficial and deleterious for the host. To do this we will use a number of established models to interrogate how the innate and adaptive systems contribute to the regulation, expansion and resolution of thrombosis. Person Specification

• - First degree in area of specialism and a PhD relevant to the research area (infectious diseases, immunology or cardiovascular sciences) with an evidenced track record of publishing papers in the relevant research area(s)
•- High level analytical capability
•- Ability to communicate complex information clearly
•- Fluency in relevant models, techniques or methods and the ability to contribute to developing new ones, with experience in one or more of the following:

• Flow cytometry (essential)

• Intravital microscopy

• Experience of animal work (essential), including holding a personal animal licence

• Tissue sectioning and immunohistology

• Confocal microscopy

- Ability to assess resource requirements and use resources effectively
•- Understanding of and ability to contribute to broader management/administration processes