Specialist, Engineering Job

Specialist, Engineering-CHE004954


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

The Specialist, Engineering, will perform lab-scale process development, including in-process assay support, for various virus vaccine projects. Responsibilities include:

Provide technical support for viral vaccine bulk manufacturing with focus on varicella zoster virus (VZV) seed manufacturing and characterization process by executing novel flow Cytometry assay and performing real time analysis of generated data to predict optimal harvest times during stock seed manufacturing batch harvest.

Coordinate and execute viral time series of manufacturing lots utilizing newly created seeds to characterize their viral propagation kinetics.

Execute laboratory scale experiments to recognize and decrease sources of variability of both the novel flow Cytometry assay and viral time series studies.

Perform technical laboratory support on manufacturing shop floor during both seed manufacturing and characterization activities.

Work with research scientists and other drug manufacturing personnel to ensure the compatibility of design and production of vaccine products and that all products are in compliance with Merck's strict quality standards as well as federal regulations.

Design, plan and generate experimental designs and perform laboratory experiments to support and/or improve full scale manufacturing process and commercialization of vaccines utilizing knowledge of molecular biology techniques, virology, organic chemistry, flow cytometry, among others.

Conduct several experiments including: cell attachment, viral progression, generation and optimization of Process Analytical Technology (PAT) for a new Stock Seed Process (Co-settling Process).

Conduct several studies in search of an optimal Trypsin Citrate supplier. Create technical documentation to communicate experiment results.

Serve as subject matter expert for the virus side of VZV seed manufacturing by performing data analysis of manufacturing trends and proposing changes to ensure a more reliable and robust production. Author Standard Operation Procedures (SOPs), including stock seed manufacturing and characterization SOP, specifically change controls to manufacturing processes, utilities, facilities and product contact components.

Proactively identify risk and implement simple, sustainable solutions aligning with technical and business strategies.

Perform and/or provide support to investigations within deviation management. Review records for cGMP compliance for accuracy and thoroughness.


Applicant must have a Bachelors Degree in Biochemistry, Chemical Engineering or Biological Sciences. Knowledge in laboratory safety protocols and equipment; Good Laboratory Practice (GLP); Molecular Biology Techniques such as gel electrolysis, DNA extraction, and DNA purification Polymerase Chain Reaction; cGMP requirements for biological products; asceptic techniques; viral plaque potency; flow cytometry; culture techniques such as cell line maintenance, media formulation, viral titration, infection, and staining; computer applications such as Minitab and Cytosoft required. Strong problem solving and hands-on laboratory skills are required. Excellent organizational, interpersonal, verbal/written communication skills required. 40 hours per week 9:00 a.m. – 5:00 p.m. Must have proof of legal authority to work in the United States.

Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at staffingaadar@merck.com.

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Job: Chemical Engineering

Job Title:Specialist, Engineering

Primary Location: NA-US-PA-West Point

Employee Status: Regular

Travel: No

Number of Openings: 1

Shift (if applicable): 1st

Company Trade Name:Merck