Senior Scientist, Neuroscience - in-vivo Job

Senior Scientist, Neuroscience - in-vivo-BIO004678


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

The Merck Early Discovery Neuroscience team is seeking a talented and motivated in-vivo scientist with a strong background in Neuroscience to join our Boston-based team to support the identification and validation of novel targets to treat CNS diseases including neurodegenerative disease such as Alzheimer’s disease and Parkinson’s disease. Candidates should be able to work independently, but will be expected to collaborate proactively and effectively with colleagues across disciplines. Primary responsibilities include basic experimental design and execution of in vivo experiments and processing of tissues and fluids for biomarker analysis. The successful candidate will have demonstrated effective teamwork and an ability to work in exploratory biology on target identification and validation projects. Merck offers a competitive compensation package commensurate with experience.

The responsibilities of the Early Discovery Neuroscience team member include:

- Design, execute and perform data analysis and report in vivo neuroscience study results.
- Assist in developing new assays, models, protocols and methods.
- Both oral and written communication of data in a clear and concise manner to the appropriate teams and stakeholders.
- Write and amend animal procedure statements.
- Monitor and review published work to guide internal research.
- Propose and assist in validating novel targets.
- Collaborate with members from other functional areas, including medicinal chemistry, in vivo and in vitro pharmacology, imaging, genetics and translational sciences.
- Work with external academic, biotechnology, and contract research organizations.



- BS/BA degree with a minimum 10 years of industry or academia experience; or an MS degree with a minimum of 10 years of industry or academia experience or a PhD with minimum 4 years post-doctoral experience preferably in neuroscience or a related subject area.


- Demonstrated ability to thrive in a team environment.
- Experience in small animal handling as well as drug formulation, dosing and tissue sampling (CSF collection, perfusions, blood and tissue collection).
- Experience with rodent stereotaxic surgeries
- Experience with behavioral assays in rodents
- Established record of innovative thinking to champion new ideas and solve problems.
- Strong data analysis skills including a practical knowledge of statistics.
- Excellent oral and written communication skills, including preparation of study reports, presentations and manuscripts for publication in peer reviewed scientific journals.


- Experience with in vitro techniques including biochemical and molecular approaches.
- Experience with in vivo microdialysis, ICV infusion/injections, mouse CSF collection.
- Experience with flow cytometry.
- Experience with microtomy and immunohistochemistry.

Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at

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Job: Biology-Discovery

Job Title:Sr. Scientist, Biology-Discovery

Primary Location: NA-US-MA-Boston

Employee Status: Regular

Travel: Yes, 5 % of the Time

Number of Openings: 1

Shift (if applicable): N/A

Hazardous Materials: chemicals and viruses

Company Trade Name:Merck