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Postdoctoral Research Fellow – Antibacterial Pharmacokinetics & Pharmacodynamics Job

Employer
Merck
Location
West Point PA
Closing date
Jan 2, 2017

Job Details

Postdoctoral Research Fellow – Antibacterial Pharmacokinetics & Pharmacodynamics-POS000216

Description

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.


Be a part of the legacy: MRL Postdoctoral Research Fellow Program

The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview:

As a postdoctoral fellow in Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) you will work with a highly collaborative team of scientists from antibacterial disease area biology, pharmacology, clinical, regulatory and scientific affairs. The aim will be to develop novel in vitro and mathematical modeling methodologies to assess how drug combinations may affect the PK/PD driver for anti-infectives with an initial focus on beta-lactamase inhibitors (BLIs), including internal BLI combinations ceftolozane/tazobactam and imipenem/relebactam. This work will be leveraged to influence emerging regulatory guidance and susceptibility breakpoint recommendations.

Responsibilities include but are not limited to:

- Generate high throughput static checkerboard in vitro data to various drug combinations with a large number of resistant bacterial strains to gain a mechanistic understanding of drug resistance

- Design and execute dynamic hollow fiber experiments utilizing Merck’s own state of the art custom setup to understand antibacterial PK/PD

- Integrate the above generated data in a systems pharmacology modeling framework to provide a greater degree of insight into fundamental characteristics of antibacterial exposure-response

- Leverage the modeling platform to provide a standardized and robust approach to deriving susceptibility testing criteria and justification of breakpoints

Qualifications

Education Minimum Requirement:

- PhD with 3 years or less of postdoctoral experience or met all the requirements for a PhD by May 2017

Required Experience and Skills:

- Experience in mathematical modeling of biological systems

- Skills in conducting experiments to assess the pharmacology of infectious disease agents

- Understanding of basic pharmacokinetic and pharmacodynamic principles

Preferred Experience and Skills:

- Experience in pharmacological characterization of antibacterials, including execution of time-kill in vitro studies

- Strong history of publication in peer-reviewed journals

- Skills in at least one of the following: NONMEM, R, Matlab, or similar tools

Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at staffingaadar@merck.com.

Search Firm Representatives Please Read Carefully:

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

For more information about personal rights under Equal Employment Opportunity, visit:

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.


Job: Post-Doctoral Fellow

Job Title:Assoc. Scientist,Post Doc Fellow

Primary Location: NA-US-PA-West Point

Employee Status: Regular

Number of Openings: 1

Company Trade Name:Merck

Company

Our vision is to make a difference in the lives of people globally through our innovative medicines, vaccines, biologic therapies, consumer health and animal products. We aspire to be the best healthcare company in the world and are dedicated to providing leading innovations and solutions for tomorrow.

We have made it our mission to provide innovative, distinctive products and services that save and improve lives, satisfy customer needs and to be recognized as a great place to work

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