We are currently seeking an independent and motivated scientist to join the research group led by Dr Anestis Tsakiridis (https://www.sheffield.ac.uk/cscb/tsakiridis). His work focuses on dissecting the molecular basis of cell fate decisions in the developing embryo and aims to exploit this knowledge for disease-modelling and regenerative medicine applications.
- The group is particularly interested in the biology of neuromesodermal progenitors (NMPs), the bipotent cell population which drives embryonic axis elongation by generating spinal cord neuroectoderm and paraxial mesoderm. We have recently described the efficient derivation of NMPs from human pluripotent stem cells (hPSCs) thus establishing a tractable system for studying these progenitors in vitro.
- You will employ this model in combination with various screens and complementary approaches aiming to define the intrinsic and extrinsic determinants of NMP maintenance and differentiation. Applicants should hold a PhD in a related field and have experience in hPSC culture/differentiation, immunocytochemistry, high content imaging and chromatin immunoprecipitation. A background in Crispr/Cas9-based genome editing and/or bioinformatics would be highly advantageous.
- You will be self-motivated, well-organised, highly independent, and willing to work with other members of the existing research team. Excellent communication, written and interpersonal skills are essential.