Skip to main content

This job has expired

PhD Research Project: The role of extra-cellular matrix remodelling in muscle-specific stem cell ac

Employer
Global Academy Jobs
Location
United Kingdom
Closing date
Dec 2, 2016

Job Details

Details

Satellite cells are adult skeletal muscle-specific stem cells responsible for post-natal muscle growth and for muscle repair upon injury or disease such as dystrophies. Satellite cells are normally quiescent. However, upon activation, satellite cells exit quiescence, begin proliferating and initiate a myogenic program that culminates with the fusion to the injured muscle fibre and its repair. An important aspect of the repair program is the ability of satellite cells to self-renew, a process that ensures the maintenance of a stem cell pool throughout life allowing the repair of future injuries. Defects in satellite cell self-renewal underlie conditions such as muscular dystrophies and sarcopenia. It is believed that the control of satellite cell quiescence, proliferation, differentiation and self-renewal is mediated through extrinsic signals produced by the satellite cell niche. We have previously shown that one such signal is delivered by the basal lamina associated with satellite cells, and is required for satellite cell self-renewal. This project aims at investigating further the mechanism of basal lamina control of satellite cell self-renewal. In particular, the project will address the relationship between the satellite cell basal lamina, cell polarity and asymmetric cell division, a process known to underlie self-renewal. The project will use a well-established ex-vivo culture system of skeletal muscle fibres, imaging and molecular biology approaches, combined with mouse genetics to gain a molecular and cellular understanding of satellite cell self-renewal.

Funding Notes

Applications from self-funded students or students with secured funding are also welcome.

Entry requirements
First class or upper second 2(i) in a relevant subject. To formally apply for a PhD Studentship, you must complete the University's application form using the following link: http://www.sheffield.ac.uk/bms/prospective_pg/how_to_apply

*All applicants should ensure that both references are uploaded onto their application as a decision will be unable to be made without this information*.

References

http://www.sheffield.ac.uk/bms/research/borycki

Company

Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."

Company info
Website

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert