Post-doctoral Research Fellow: Structural Mechanism of Amyloid Formation

United Kingdom
Oct 13, 2016
Nov 10, 2016
Organization Type
University and College
Full Time
“The molecular mechanisms of structural conversion in amyloid disease”

Applications are invited for a Wellcome Trust-funded postdoctoral research assistant to join a dynamic interdisciplinary team focusing on using a combination of biophysical and biochemical methods to investigate the mechanisms of protein aggregation into amyloid fibrils in vitro. The project will focus on the aggregation of beta-2-microglobulin into amyloid fibrils which is associated with the disorder dialysis related amyloidosis. The person appointed will be a specialist in NMR spectroscopy applied to protein systems and will use a wide range of NMR and other biophysical methods to determine the structure and dynamics of intermediates In amyloid assembly and the molecular recognition events that govern assembly into amyloid fibrils. In addition, by mapping the interfaces involved in amyloid formation, you will develop protein aptamers able to inhibit amyloid formation and test their effects in vitro.

The project is funded jointly between the laboratories of Professors Sheena Radford, and Dr Eric Hewitt within the Astbury Centre for Structural Molecular Biology at the University of Leeds. You should have (or be close to completing) a PhD in biochemistry or a related area. Experience in NMR spectroscopy and/or characterisation of proteins using biophysical methods is required.

Informal enquiries to may be made to Prof Sheena E Radford, email
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