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PhD studentship: BBSRC White Rose DTP - How do post-translational modifications control the physiol

Employer
Global Academy Jobs
Location
United Kingdom
Closing date
Jan 5, 2017

Job Details

Details

Campylobacter jejuni is the most common cause of food-borne gastroenteritis in the western world. Human infections result from consumption of contaminated chicken and the incidence has increased in recent years, including the emergence of multi-drug resistant campylobacters. New interventions are needed to reduce the numbers of the bacteria in the food-chain. We know that may essential proteins in bacteria are controlled by covalent modifications to their structure. This project will seek to understand the role of protein phosphorylation in the regulation of metabolism of C. jejuni using cutting-edge proteomics analyses employing high-resolution mass spectrometry combined with biochemical analysis of protein function. Our approach may allow the identification of new targets for anti-microbial drugs or other interventions to reduce the burden of Campylobacteriosis. This interdisciplinary project will provide training in molecular microbiological techniques including mutant construction and global protein expression analysis, as well as the application of proteomic techniques to an important biological problem.

For further information contact Professor David Kelly (d.kelly@sheffield.ac.uk)

Funding Notes

4 year BBSRC studentship, under the BBSRC White Rose Mechanistic Biology DTP.

We welcome applications from students with first degrees in Biological, Chemical or Physical Sciences. For successful applicants, the studentships would provide funding for tuition fees and living stipend at the current Research Council UK rates (subject to eligibility). Please note that EU citizens must have lived in the UK for at least 3 years to be eligible for full support.

Applicants should have or expect to achieve an undergraduate honours degree at 2.1 or higher in a relevant field

 

References

AL-HAIDERI, H., WHITE, M.A, AND KELLY, D.J. (2016) Major contribution of the type II beta carbonic anhydrase CanB (Cj0237) to the capnophilic growth phenotype of Campylobacter jejuni. Environmental Microbiology 18, 721-735.

LIU, Y-W. AND KELLY, D.J. (2015) Cytochrome c biogenesis in Campylobacter jejuni requires cytochrome c6 (CccA; Cj1153) to maintain apocytochrome cysteine thiols in a reduced state for haem attachment. Molecular Microbiology 96, 1298-1317.

KENDALL, J.J., BORRERO-TOBON, A., HENDRIXSON, D. AND KELLY, D.J. (2014) Hemerythrins in the microaerophilic bacterium Campylobacter jejuni help protect key iron-sulphur cluster enzymes from oxidative damage. Environmental Microbiology 16, 1105-1121

MATHIEU BROCHET, MARK O COLLINS, TERRY K SMITH, ELOISE THOMPSON, SARAH SEBASTIAN, KATRIN VOLKMANN, FRANK
SCHWACH, LIA CHAPPELL, ANA RITA GOMES, MATTHEW BERRIMAN, JULIAN C RAYNER, DAVID A BAKER, JYOTI CHOUDHARY AND OLIVER BILLKER (2014). Phosphoinositide biosynthesis links cGMPdependent protein kinase to essential Ca2+ signals at key decision points in the life cycle of malaria parasites. PLoS Biology 4;12(3):e1001806.

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Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."

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