Phd - Role of Class I PI3 kinase in platelet-leukocyte interactions, innate immunity and deep vein
- Employer
- Global Academy Jobs
- Location
- United Kingdom
- Closing date
- Dec 5, 2016
View more
- Sector
- Science, Life Sciences, Cell and Molecular Biology
- Hours
- Full Time
- Organization Type
- University and College
- Jobseeker Type
- Academic (e.g. 'Lecturer')
Job Details
We and others have previously shown that the Class I family of PI3 kinases is involved in platelet hyperactivity and enhanced thrombus formation, as well as increasing platelet function downstream of P2Y12, an established anti-platelet drug target. PI3 kinase not only directly affects platelet function, but also feeds into the PLA2/COX pathway, thereby stimulating release of eicosanoids and various lipids that in turn can activate leucocytes, stimulate NETs formation and DTV. Although generic PI3kinase inhibitors inhibit platelet-leucocyte interactions, the underlying mechanism by which Class I PI3 kinase regulates platelet-leucocyte interactions and contributes to deep vein thrombosis is still largely unknown. In this study, we therefore aim to explore the role of Class I PI3 kinase in platelet-leucocyte interactions, activation of the innate immune response/NETs formation and its contribution to deep vein thrombosis in in vivo mouse models. We will focus on the role of different Class I isoforms in platelets and leucocytes by targeting individual Class I isoforms both pharmacologically (isoform selective inhibitors) in human and mouse platelets as well as genetically (conditional Class I isoform specific knock out mice). This is a novel and important area of research that will further elucidate cross-talk between platelets and innate immunity, and although challenging, has high feasibility in generating results within the PhD period. Together, this project will combine a range of different approaches and disciplines, including functional cell biology, cell signalling/biochemistry, imaging, mass spec lipodomics, computational analysis and in vivo mouse models to elucidate the role and underlying mechanism by which Class I PI3kinases contribute to platelet-leucocyte cross-talk and deep vein thrombosis.
Funding Notes
This is a 4 year studentship funded by the South West Biosciences Doctoral Training Partnership (SWBio DTP) and covers: a stipend (at the standard Research Councils UK rate; currently £14,296 per annum for 2016-2017), research and training costs, tuition fees and additional funds to support fieldwork, conferences and a 3-month internship
For full details on eligibility and how to apply please go to the following links: View Website and View Website PLEASE ENSURE that you select the Faculty of Biomedical Sciences and the programme choice South West Biosciences Doctoral Training Partnership (PhD)
Supervisor: Dr Hers
Company
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