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Phd - BBSRC MIBTP - Determining novel molecular regulators of necrosis controlling neuronal cell de

Employer
Global Academy Jobs
Location
United Kingdom
Closing date
Jan 9, 2017

Job Details

Details

Multiple forms of programmed cell death have been discovered in the past four decades. Among these, apoptosis is the most studied so far with evolutionarily conserved regulatory machineries reported. Recently, regulated necrosis, another type of programmed cell death, has been identified as an alternate to kill cells especially in pathological conditions when apoptosis is defective. However, our knowledge about regulation of necrosis is still very limited which is partly due to lack of in vivo assays for systematic analyses. To address this, we have established a model of regulated necrosis controlling neuronal death in Drosophila, an organism with advantages of genetic manipulation. Intriguingly, our study has revealed the analogy of necrosis regulation in Drosophila with its mammalian counterpart suggesting the feasibility of using Drosophila models to further dissect regulation of necrosis. This PhD project is an initiative to systematically identify and characterise novel regulators of necrosis in an intact organism and explore their roles in controlling neuronal cell death.

Funding Notes

This studentship is competition funded by the BBSRC MIBTP scheme: http://www.birmingham.ac.uk/research/activity/mibtp/index.aspx
Deadline: January 8, 2017
Number of Studentships available: 30
Stipend: RCUK standard rate (plus travel allowance in Year 1 and a laptop).
The Midlands Integrative Biosciences Training Partnership (MIBTP) is a BBSRC-funded doctoral training partnership between the universities of Warwick, Birmingham and Leicester. It delivers innovative, world-class research training across the Life Sciences to boost the growing Bioeconomy across the UK.
To check your eligibility to apply for this project please visit: http://www2.warwick.ac.uk/fac/cross_fac/mibtp/pgstudy/phd_opportunities/application/

References

Fan Y.* and Bergmann A. (2014). Multiple mechanisms modulate distinct cellular susceptibilities towards apoptosis in the developing Drosophila eye. Dev Cell, 30(1):48-60. (*corresponding author) 

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Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."

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