Skip to main content

This job has expired

PhD Research Project: BBSRC MIBTP - Understanding Multiple Antibiotic Resistance in Gram-negative B

Employer
Global Academy Jobs
Location
United Kingdom
Closing date
Jan 9, 2017

Job Details

Details

Antibiotics have transformed medical practice, increased life expectancy and, together with vaccination, led to the near eradication of many bacterial diseases1. However, overuse, including in animals, has potentiated the emergence of resistant bacteria. Such bacteria now cause millions of infections annually, with thousands of lives lost at a societal cost of billions of dollars. Moreover, the occurrence of untreatable infections is increasingly common. This disturbing trend is an immediate threat to health in every region of the world; antibiotic-resistant bacteria have the potential to affect anyone, of any age, in any country. The multiple antibiotic resistance (mar) regulon, and homologous systems, are continually implicated. Briefly, the mar operon encodes a global gene regulatory system that controls expression of genetic determinants which confer antibiotic resistance. We hypothesise that the majority of targets for MarA, and the underlying molecular mechanisms of antibiotic resistance, are undefined. This project will combine genomic tools with focused molecular biology to identify new mechanisms of antibiotic resistance and new drug targets.

Funding Notes

This studentship is competition funded by the BBSRC MIBTP scheme: http://www.birmingham.ac.uk/research/activity/mibtp/index.aspx
Deadline: January 8, 2017
Number of Studentships available: 30
Stipend: RCUK standard rate (plus travel allowance in Year 1 and a laptop).
The Midlands Integrative Biosciences Training Partnership (MIBTP) is a BBSRC-funded doctoral training partnership between the universities of Warwick, Birmingham and Leicester. It delivers innovative, world-class research training across the Life Sciences to boost the growing Bioeconomy across the UK.
To check your eligibility to apply for this project please visit: http://www2.warwick.ac.uk/fac/cross_fac/mibtp/pgstudy/phd_opportunities/application/
 

References

Alekshun MN, Levy SB. (2007) Molecular mechanisms of antibacterial multidrug resistance. Cell. 128:1037-50.
Blair JM, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJ. (2015) Molecular mechanisms of antibiotic resistance. Nat Rev Microbiol. 13:42-51.

Company

Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."

Company info
Website

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert