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PhD Research Project: Understanding chromatin organisation in cell nucleus: multiscale approaches t

Employer
Global Academy Jobs
Location
United Kingdom
Closing date
Jan 31, 2017

Job Details

Details

Take a bunch of different coloured spaghetti and bring them to a boil in a pot. The spaghetti ends up in a gooey mess all entangled. In contrast, human chromosomes, that may be visualized as “cellular spaghetti” is organised in distinct regions or “territories” inside the cell nucleus. How the cell, formed of compliant parts, achieves such tight control is not yet clear despite several experimental and theoretical studies. This is a theoretical project and will focus on extending ideas of polymer physics and non-equilibrium statistical mechanics to understand chromosome organization inside the cell nucleus along its development pathway. A coarse-grained model of chromosome organization that leads to gene regulatory networks at the macroscale will be developed. This would also help understand how stem cells are intrinsically different from differentiated ones at the microscopic level and pave the way forward for a statistical understanding of stem cell biology, and chromosomal abnormalities.

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Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."

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