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Early Stage Researchers (for PhD Studies), Childhood and Adolescence Psychopathology: unravelling t

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The University of Bristol invites applications for two Early Stage Researcher (ESR) Fellowships for PhD studies funded as part of the Marie Curie European Training Networks, under the European Commission’s H2020 Framework Programme.

The recruited ESRs will join the CAPICE project: “Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe” (with a 3-year Marie Curie fellowship).  

A total of 12 ESRs for PhD will be hosted across this network and will be trained in the broad field of psychiatric genomics. Candidates with a background in statistical genetics, bioinformatics, psychology, psychiatry or neuroscience are invited to apply.

Project 1 Lifestyle behaviours during pregnancy and offspring psychiatric outcomes: Using Mendelian randomization to infer causality.

The aim of this project is to explore the relationships between lifestyle behaviours in the mother during pregnancy (e.g., tobacco and alcohol use) and later psychiatric outcomes in the offspring through childhood and into early adulthood.

Analyses will include the development and validation of polygenic risk scores for various lifestyle behaviours (e.g., tobacco, alcohol, caffeine and cannabis use), and their application using Mendelian randomization methods to understand whether there is causal effect of these exposures on offspring psychopathology.

Project 2 Two-step Mendelian randomization analyses of lifestyle behaviours during pregnancy and offspring psychiatric outcomes.

The aim of this project is to conduct two-step Mendelian randomization analyses of lifestyle behaviours in the mother during pregnancy, to determine whether DNA methylation mediates the relationship between exposures in pregnancy and psychiatric outcomes in the offspring.

Analyses will include epigenome-wide association analyses to explore the relationship between environmental exposures and methylation, and Mendelian randomization techniques to explore whether DNA methylation underlies the association between these exposures and offspring outcomes.

Requirements:

The candidates must have a Masters degree in a relevant discipline (e.g., statistics, statistical genetics, psychology), and have good knowledge and/or interest in childhood psychopathology and the impact of intrauterine exposures on these outcomes.

Candidates will be required to meet the Marie Skłodowska-Curie Early Stage Researcher eligibility criteria: (http://ec.europa.eu/research/mariecurieactions/). In particular, at the time of appointment candidates must have had less than four years full-time equivalent research experience and must not have already obtained a PhD. Additionally, they must not have resided in the UK for more than 12 months in the three years immediately before the appointment. 

Application:

Please send your CV and motivation letter to the project manager of the CAPICE project, Natascha Stroo, n.stroo@vu.nl before March 1st, 2017

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