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Research Fellow - Structure-based Cancer Drug Discovery and Biophysics

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Are you an ambitious researcher looking for your next challenge? Do you have an established background in structural biology and biophysical methods, including biomolecular NMR? Do you want to further your career in one of the UKs leading research intensive Universities?

Based in the Laboratory of Prof. Alex Breeze in the Astbury Centre for Structural Molecular Biology and in collaboration with partners based at Newcastle University (Prof Mike Waring, Department of Chemistry) you will work on the design of allosteric inhibitors of the Ras exchange factor, SOS.

The project is funded by the Pancreatic Cancer Research Fund and will involve fragment-based compound screening, structural analysis using X-ray crystallography and NMR spectroscopy, and biophysical and computational analysis of binding interactions. Exceptional facilities are available in Leeds to support the project, including a new, 950 MHz cryoprobe-equipped NMR spectrometer and state-of-the-art X-ray crystallography and biophysics infrastructure.

We are looking for a highly multidisciplinary and collaborative Postdoctoral Researcher who has a PhD (or is close to completion) in structural biology and a developing track record of peer reviewed publications in international journals. You will have experience in use of biophysical methods (e.g. SPR, ITC), and an enthusiasm and aptitude to learn to enable you to continue your professional development.

To explore the post further or for any queries you may have, please contact:

Prof Alex Breeze, Professor of Biomolecular NMR

Tel +44 (0)113 343 0087, email a.l.breeze@leeds.ac.uk

 

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