Associate Principal Scientist, Protein Mass Spectrometry Job

Associate Principal Scientist, Protein Mass Spectrometry-CHE005215

Description

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.


The Mass Spectrometry Capabilities group within the Screening & Compound profiling Department is seeking a highly skilled scientist to fill the position of Associate Principal Scientist, Protein Mass Spectrometry and join our team of experienced and accomplished colleagues. The individual will have the following responsibilities:

- Utilize hydrogen-deuterium exchange mass spectrometry (HDX-MS) and related techniques (native protein & ion mobility analysis) to characterize protein higher order structure and dynamics, as well as ligand-protein and protein-protein interactions.
- Develop LC-MS methods to quantify proteins & peptides in a range of settings (purified & reconstituted in detergents, nanodiscs, etc; membrane fractions; cells).
- Perform intact protein and peptide mapping experiments to identify cleavage patterns, covalent modification, PTMs and differential expression patterns.
- Apply classical protein biochemistry and biophysical techniques including gel electrophoresis, enzymatic digestion, western blotting, ELISA immunoassay, protein/peptide fractionation, SEC, DLS and others.
- Contribute to scientific supervision, skill development and mentoring for colleagues.
- Act as liaison on projects between research sites (NJ, PA and MA), including travel up to 10% of time.
- Maintain a strong, external scientific reputation for the Screening & Compound Profiling department through publications and presentations.
- Please note that this position is laboratory-based.

Qualifications

Education:

- Ph.D degree in Analytical Chemistry, Biochemistry, Pharmacology or other relevant field

Required:

- At least 5 years of hands-on experience practicing protein mass spectrometry in a relevant industrial field.
- Demonstrated knowledge and experience in proteomics OR HDX-MS for structural characterization.
- Strong external record of scientific achievement (via publications, presentations, etc.).
- Strong interpersonal, verbal and written communication skills.

Preferred:

- Knowledge of non-MS based structural techniques, including bioNMR, crystallography, modeling and associated analysis tools would be a significant advantage.
- Prior experience in the characterization of membrane proteins (GPCRs, ion channels, transporters) would be a significant advantage.
- Prior experience with engineering, expression and purification of proteins using classical techniques is advantageous.
- Previous experience studying protein kinetics via incorporation of stable isotopes (amino acids, deuterated water) is desirable.
- Previous experience with immunoaffinity enrichment for quantitative LC-MS measurement of proteins in cells, biofluids and/or tissues is desirable.

Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at staffingaadar@merck.com.

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.


Job: Chemistry

Job Title:Assoc Prin. Scientist, Chemistry

Primary Location: NA-US-NJ-Kenilworth

Employee Status: Regular

Travel: Yes, 10 % of the Time

Number of Openings: 1

Company Trade Name:Merck