PhD student in molecular biology/bioinformatics or related field

We are passionate about science and our projects are focused on post-transcriptional gene expression regulatory
mechanisms (http//adz.ibb.waw.pl). We perform collaborative, integrative science and combine functional studies with
transciptomic and proteomic analysis in order to gain deep insight into analyzed processes [Ukleja, M., et al. (2016). Nature
communications 7, 10433; Wrobel, L., et al. (2015). Nature 524, 485-488; Szczepinska, T., et al. (2015). Genome research
25, 1622-1633; Lubas, M., et al. (2013). The EMBO j 32, 1855-1868; Mroczek, S., et al. (2012). Genes & development 26,
1911-1925; Pena, A., et al. (2012). EMBO J 31, 1605-1616; Tomecki, R., et al. (2010); Lubas, M., et al. (2011). Molecular
cell 43, 624-637; EMBO J 29, 2342-235; Lebreton, A., et al. (2008). Nature 456, 993-996)]
The laboratory is well equipped and has very supportive technical staff. We work in the Institute of Biochemistry
and Biophysics of the Polish Academy of Sciences (ibb.waw.pl) - one of the top ranked Polish research institutes which is
a part of the Ochota Campus, a large biomedical research center in Poland.
Open positions are funded by Foundation for Polish Science TEAM program (http://www.fnp.org.pl/en/oferta/team-
2-2/) co-financed with support of the Smart Growth Operational Programme (PO IR).
The project entitled ”Functional interactions of proteins involved in post-transcriptional regulatory mechanism in
humans” focuses on identification of novel factors involved in RNA metabolism and description of novel functional
interactions between the existing ones. It is based on genome wide siRNA screenings, a methodology which was recently
implemented in the laboratory.
To explore factors and relationships in human RNA catabolism we conduct multiple synthetic lethal screens involving
human exonucleases and siRNA library which covers almost all human genes. The screening is a starting point for more
detailed molecular analysis specific for particular identified functional interactions. It is divided into two parts:
Molecular analysis of functional interactors of the DIS3 protein
Identification and analysis of functional interactors of DIS3L, DIS3L2, RRP6, XRN1 and XRN2
 
Please e-mail CV, summary and relevance of your current research (500 word max), why you are interested in the position

(200 word max) and names of up to three references to: team.project.ad@gmail.com. Application deadline: 31th March
2017
Selected candidates only will be contacted with invitation for a final interview.
Please include in your CV a statement:
“I hereby give consent for my personal data included in the job offer to be processed for the purposes of recruitment
under the Data Protection Act 1997 (Dz. U. no. 133, item 883), consolidated text:Journal of Laws 2016, item 922 as
amended.