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Research Fellow, Institute of Microbiology and Infection

Employer
Global Academy Jobs
Location
United Kingdom
Closing date
May 25, 2017

Job Details

Job Purpose

The research group of Prof. Van Schaik at the Institute of Microbiology and Infection of the University of Birmingham has a vacancy for the position of a full-time post-doctoral researcher (2 years) on a research project which aims to elucidate the gene exchange networks of antibiotic resistance genes in complex microbial ecosystems.

Infections caused by antibiotic resistant bacteria have become a major threat to public health. Hospitalized patients are at a particularly high risk to develop infections with antibiotic-resistant bacteria. The majority of hospital-acquired, antibiotic-resistant infections are caused by a relatively limited number of bacterial species. The Gram-negative Klebsiella pneumoniae and the Gram-positive Enterococcus faecium are among the most prominent multi-drug resistant nosocomial pathogens. In this project we will elucidate how the opportunistic pathogens Klebsiella pneumoniae and Enterococcus faecium can acquire antibiotic resistance determinants by horizontal gene transfer from other bacteria in complex microbial ecosystems, including the human gut microbiota and sewage.

Innovative metagenomic techniques will be used to link resistance genes to their bacterial hosts. Bacterial harbouring resistance genes will be enriched by a multiplex culture approach, using a variety of growth conditions Upon isolation of the strains, their genomes will be sequenced using a combination of short- and long-read sequencing, leading to the complete assembly of the chromosome and plasmids. The ability of these bacteria to serve as donors of resistance genes to K. pneumoniae and E. faecium strains will then be assessed by conjugation assays in laboratory media, in hospital sewage and in conditions that mimic the human gut.
We are looking for a creative, independent and ambitious candidate with a PhD degree in microbiology. Experience in metagenomics, molecular genetics and/or bioinformatics are preferred. The candidate should enjoy teamwork and should have excellent communication skills.

Person Specification

• First degree in area of specialism and normally, a higher degree relevant to research area or equivalent qualifications
• High level analytical capability
• Ability to communicate complex information clearly
• Fluency in relevant models, techniques or methods and ability to contribute to developing new ones
• Ability to assess resource requirements and use resources effectively
• Understanding of and ability to contribute to broader management/administration processes

Company

Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."

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