Research Technician, Medical and Dental Sciences
The study will identify a ‘druggable target’ within the cochlear nucleus to alleviate the symptoms of noise-induced tinnitus. The study arises from our research demonstrating a considerable loss of the inhibitory 5-HT1A receptor within the cochlear nucleus evident in two animal models of tinnitus (noise-induced and salicylate-induced animal models of tinnitus). Hence our hypothesis is that a reduction in inhibition within the cochlear nucleus gives rise to excitation that manifests tinnitus.
Immunohistochemical studies will be performed with rat brain tissue to identify and phenotype the 5-HT1A receptor expressing cells in the cochlear nucleus of rats. As part of the phenotyping process of the 5-HT1A receptor expressing cells, we will investigate the expression of additional receptors to select suitable receptor candidates to pharmacologically manipulate to mimic the action of the 5-HT1A receptors and normalize activity in the cochlear nucleus.
This key post will provide technical support to a postdoctoral researcher (Dr Gillian Grafton), performing the immunohistochemical aspects of the project. The post holder will contribute directly to the research project by conducting in vitro and in vivo experiments using a variety of techniques. The appointment of a technician will expedite delivery of the project and allow Dr Grafton, an experienced researcher whose skills are required to allow likely completion of the proposed work within an 18-month period, to concentrate on the more challenging aspects of the project.
• NVQ, BTEC/ONC or equivalent; or specific relevant experience in an appropriate subject.
• GCSE (A*- C) or equivalent in mathematics
• Proven practical experience of relevant techniques required for the post
• Positive service attitude and shows courtesy in dealing with others
• Ability to organise and manage own work load after consultation with supervisor and demonstrate flexibility in terms of work practices/requirements
• Ability to work as part of a team but to perform under minimum supervision
• Awareness of current relevant H&S policies
• Proficiency in commonly used software packages
• Willingness to work towards professional registration