Research Fellow on Single-Molecule and Superresolution Microscopy Applied to GPCR Signalling

Job Purpose

A postdoc position is available in the Calebiro lab at the University of Birmingham, Institute of Metabolism and Systems Research (IMSR), to investigate G protein-coupled receptor (GPCR) signalling by single-molecule and superresolution microscopy.

The successful applicant will join a multidisciplinary research programme aimed at unravelling the function of membrane receptors using high-end optical methods. The team is part of the recently opened Centre of Membrane Proteins and Receptors (COMPARE), a state-of-the-art imaging facility established as a strategic partnership between the Universities of Birmingham and Nottingham.

The applicant will utilize innovative microscopy methods such as single-molecule microscopy/single particle tracking and superresolution imaging (dSTORM) to analyse the composition and dynamics of receptor signalling nanodomains in simple cell systems as well as in hippocampal neurons and organotypic brain slices.

Person Specification

• An excellent PhD in a relevant area
• Background in biophysics, cell biology and/or bioinformatics
• Preferably, experience with advanced microscopy methods such as single-molecule microscopy and/or superresolution imaging
• Experience with cell culture, preferably including the isolation of primary cells (e.g. primary hippocampal neurons)
• High level analytical capability
• Ability to communicate complex information clearly
• Ability to assess resource requirements and use resources effectively