Research Fellow in Biological NMR/Biophysics

Are you looking to apply your skills in Biochemistry/Biophysics to help gain a new molecular understanding of how proteins assemble into amyloid fibrils and to develop new routes to treating amyloid disease?

Job Details

We are looking for an outstanding postdoctoral research fellow to join a Wellcome Trust-funded team which will ultimately involve four post-doctoral researchers investigating the mechanisms of protein aggregation into amyloid fibrils using chemical biology, biochemistry, biophysics, structural biology, cell biology and experiments in C.elegans models of amyloid disease. You will have expertise in the analysis of protein structure and dynamics using modern biomolecular NMR approaches combined with computational analysis and/or other biophysical and biochemical methods. The project focuses on mapping the earliest protein-protein interactions that commit proteins to aggregate into amyloid and to discover new routes to prevent these interactions using small molecules or novel protein scaffolds (affimers) selected using phage display.

You will be based in the laboratory of Professor Sheena Radford and will work closely with Professor Alex Breeze, our collaborators and other members of the amyloid team. You will have a PhD (or be close to completion) in Chemistry, Biochemistry, Biophysics or a related discipline. You will also have experience of using NMR methods to analyse protein structure and dynamics, combined with computational analysis of proteins and protein complexes. Experience in the use of other biophysical techniques to analyse protein structure, folding and ligand binding would also be advantageous.

Further information about the project and recent publications are available within the additional information document.

To explore the post further or for any queries you may have, please contact:

Professor Sheena E Radford, Astbury Professor of Biophysics

Tel: +44 (0)113 343 3170, email: s.e.radford@leeds.ac.uk