PhD Studentship: Application of advanced engineering imaging and image based modeling approaches to
- Employer
- Global Academy Jobs
- Location
- United Kingdom
- Closing date
- Jun 30, 2017
View more
- Sector
- Science, Life Sciences, Cell and Molecular Biology, Physical Sciences and Engineering, Chemical Engineering, Chemistry, Biochemistry
- Hours
- Full Time
- Organization Type
- University and College
- Jobseeker Type
- Academic (e.g. 'Lecturer')
Job Details
In this project we will develop an image-based mathematical model of the lung lymphatic fluid flow and tissue drainage and use this model to assess how the structure influences the immune response. To do this we use multimodal imaging of X-ray computed tomography to observe 3D structure in combination with immunohistochemical methods to map of the rat lung lymphatic and vascular systems. This will allow us to identify the key structural features that change with the physiological adaptation of the lymphatic system in response to inflammation and most crucially enable future experiments in silico, thus contributing to the reduction of the use of animals in research. Having developed the imaging and modelling work stream we will use images from challenged and unchallenged individuals to then test in silico the hypothesis that functional capacity of the lymphatic network responds dynamically to challenge with, for example, allergens, infectious agents, toxins or lung damaging chemicals, and thus contributes to repair and fluid clearance and the movement of infectious or toxic agents into the body. This will help identify the type and location of relevant changes associated with allergen challenge, informing our understanding of lymphatic physiology.
This work will be carried out in collaboration with DSTL who will provide co-supervision of the PhD student and materials necessary for conducting the study.
This PhD project will be funded as part of the UK governments new Industrial Strategy. The scholarship will cover full UK fees and a stipend of between £16k and £18k per year depending on academic qualifications.
If you wish to discuss any details of the project informally, please contact Tiina Roose of Bioengineering Sciences Research Group, Email: t.roose@soton.ac.uk
Company
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