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PhD Studentship: Diet and mTor signalling in ageing-related neurodegenerative disease

Employer
Global Academy Jobs
Location
United Kingdom
Closing date
Feb 5, 2018

Job Details

Details

Reducing food intake robustly increases lifespan in model organisms. When this data is extrapolated to humans, the predicted gain in healthy lifespan beats curing all stroke, diabetes, cancer and cardiac disease. Unfortunately, mechanisms of this diet effect have remained highly elusive. The mTor signalling network, able to also reliably extend longevity, is strongly modulated by diet. Yet, the longevity benefits of diet have so far been shown to be largely independent of mTor.
We have now identified in a Drosophila model of frontal temporal dementia that downregulation of a specific mTor signalling component negates any effect of diet on the disease phenotype. This opens up an exciting opportunity to investigate the intricate and important relationships between diet, ageing and mTor signalling using this in vivo disease-relevant model. You will use a wide range of genetic tools using powerful genetic high-throughput models to understand these intricate relationships. You will further integrate your findings into neuroscience by spending time in the Sweeney lab (York).
The work is multidisciplinary as it crosses boundaries between nutritional science, neuroscience and ageing research. The research environment is an ambitious group with a strong team spirit and with widely divergent skill sets from which you will benefit.

 

Funding Notes

The decision on funding for this project is pending.

Applications are welcome from both UK and EU nationals (residency requirements apply).


Applicants must have, or expect to gain, at least an Upper Second Class degree.




 

Company

Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."

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