Research Associate / Senior Research Associate-Cell Biology of Cell Competition

Location
United Kingdom
Posted
Feb 02, 2018
Closes
Mar 28, 2018
Organization Type
University and College
Hours
Full Time
Post-doctoral position on the Cell Biology of Cell Competition

A postdoc position (Senior / Research Associate) is available to join the group of Eugenia Piddini to investigate the cell biology of cell competition in Drosophila.

Cell competition is a fundamental phenomenon that allows fitter cells (or ‘winners’) to kill less fit cells (‘losers’) and colonize tissues in their stead. Research in the Piddini group seeks to understand the mechanisms and function of cell competition and how it modulates cell colonization in tissues and organs. We use an integrated approach that combines genetics and whole tissue in vivo studies in Drosophila with in vitro quantitative approaches using mammalian cells (http://research-information.bristol.ac.uk/en/person/eugenia.piddini). Our ultimate goal is to identify how cell competition can be harnessed to develop novel therapeutic strategies in cancer and in regenerative medicine.

We are seeking to appoint an outstanding post-doc to investigate the mechanisms and signaling pathways involved in cell competition using Drosophila genetics and in vivo models of cell competition. The project will investigate the cell biology underpinning cell competition. A focus of this work will be on the oxidative stress response, which our group has recently discovered is sufficient to induce the loser status and to trigger the elimination of cells activating this response by wild-type cells.

Applicants should be highly motivated and have a substantial track record of productivity and international experience. They should have a PhD in a relevant subject area, or be close to completion of their degree. Prior expertise in cell and/or developmental biology or experience in cell signaling are required. Prior experience with Drosophila models is favoured but is not essential.

Applications should include a CV and a brief statement outlining key areas of expertise and reasons why you would like to join our group.

Informal enquiries can be addressed to Professor Eugenia Piddini: eugenia.piddini@bristol.ac.uk. The funds for this post are available for 2 years in the first instance.

The closing date for applications is midnight on Wednesday 28 March 2018.

The University is committed to creating and sustaining a fully inclusive culture.  We welcome applicants from all backgrounds and communities.