PhD Studentship - What is the limiting step in pathogenic tau transmission along neuronal networks?

Application Deadline: 26/3/18

Interviews will be held in April

PhD Description: 

Neurofibrillary tangles formed of misfolded tau protein are found in a range of neurodegenerative diseases. Self-propagation of the conformational change across the brain contributes to disease progression, however, the cellular mechanisms underlying the transmission of toxic protein species are not well understood. This project will dissect the earliest steps of seeded misfolding using biochemical and cell biological techniques. These will include the use of fluorescent and bioluminescent reporter assays and microfluidic co-culture platforms developed by the group. Experience in cell biology and/or molecular biology will be essential, with a background in neuroscience desirable.

The project is funded for 3 years and welcomes applicants from the UK and EU who have or expect to obtain at least an upper second class degree in Biological Sciences or allied subjects. Funding will cover fees and a stipend at current research council rates of £ 14,777 per annum for 2018/19. 

Due to funding restrictions this position is only open to UK/EU applicants

Applications for an MPhil/PhD in Biological Sciences should be submitted online at:

https://studentrecords.soton.ac.uk/BNNRPROD/bzsksrch.P_Login?pos=4973&majr=4973&term=201819  Please place Dr Katrin Deinhardt’s name in the field for proposed supervisor.

General enquiries should be made to Katrin Deinhardt at: K.Deinhardt@soton.ac.uk.  Any queries on the application process should be made to pgafnes@soton.ac.uk

Applications will be considered in the order that they are received, and the position will be considered filled when a suitable candidate has been identified.

The University of Southampton and Biological Sciences both hold an Athena Swan Silver & Bronze Award, respectively, demonstrating their commitment to provide equal opportunities and to advance the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine.   Due consideration will be given to applicants who have taken a career break.  University benefits include onsite childcare facilities, state-of-the-art on-campus sports, arts and culture facilities, a full programme of events and a range of staff discounts.