Sr. Scientist, Target and Pathway Discovery for Neurodegenerative Disease Job

Boston MA
Nov 01, 2016
Nov 23, 2016
Organization Type
Sr. Scientist, Target and Pathway Discovery for Neurodegenerative Disease-BIO004625


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

Merck Research laboratory is seeking an experienced laboratory scientist for implementing studies that inform on new drug targets and disease-relevant pathway for therapeutic intervention in neurodegenerative diseases. The Neuroscience Target and Pathway Biology has a particular interest in understanding how defects in neural development and neural activity may lead to Parkinson’s and Alzheimer’s disease. We are applying cutting edge high-throughput functional genomics technology and disease relevant rodent primary and human iPSC derived neuronal models to translate human clinical genetic findings into targets and drugs.

The candidate will bring expertise in neuroscience and neurodegenerative diseases and in vitro cell based assay development and an understanding of human genetics. She/he will join the Target and Pathway Biology group within the department of Genetics & Pharmacogenomics (GpGx) at MRL Boston. The mission of GpGx is to leverage human genetics and cutting edge molecular biology technologies to identify and functionally validate novel targets and pathways for therapeutic intervention.

The primary responsibilities of the candidate will include:

- Development of medium throughput cell-phenotypic assays for proof-of-concept functional studies, target validation and compound screening

- Validation of hit genes and compounds for follow-up mechanistic studies and lead-optimization

- Independent leadership of projects with minimal supervision

- Maintaining broad knowledge of literature and state-of-the-art technology

- Witten and verbal communication of study plans and results to project lead and more broadly at team and departmental levels

- Interface broadly with GpGx and Neuroscience Therapeutic Area scientists, Discovery, and Preclinical Pharmacology teams



- PhD with 4+ years of academic or industry experience, preferably in neuroscience, human stem cell biology, genomics or cell biology, or a related field


- Expertise in neuroscience

- Expert knowledge in establishing and working with human and murine in vitro and neuronal models, such as human iPSC derived neurons OR primary rodent neurons cells

- Direct experience in development of in vitro phenotypic assays such as high content imaging, FLIPR and multi-electrode array (MEA)

- Experience in, or aptitude for, genomics technologies such as CRISPR, RNAi and in vitro viral delivery methods

- Strong communication, collaboration, and leadership skills, including an ability to communicate experimental design, results and conclusions in a clear and concise manner to biologists, chemists, and senior management

- Other requirements include strong data analysis skills, and high level of flexibility to thrive in a dynamic environment


- Good understanding of human genetics and its application to inform assay and preclinical model development for novel gene discovery
* Expertise in neurodegenerative disorders

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Job: Biology-Discovery

Job Title:Sr. Scientist, Biology-Discovery

Primary Location: NA-US-MA-Boston

Employee Status: Regular

Number of Openings: 1

Shift (if applicable): 1st

Company Trade Name:MSD

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