Associate Principal Scientist, Cell Line Development Job

Associate Principal Scientist, Cell Line Development-PRE000587


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its 125-year legacy. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

Cell Line Development is seeking a highly motivated and experienced Associate Principal Scientist to help develop and characterize early and late stage mammalian commercial cell lines to support innovative biological pipeline projects. The successful candidate should have industrial experience related to commercial CHO cell line development.

Candidate must have experience in an in-depth understanding of cell biology/molecular biology and hand-on experience of molecular subcloning, vector design, mammalian culture and cloning. Candidate must have experience in executing complex study designs requiring highly organized data collection and management. The selected candidate will be expected to work independently, including proactive planning, trouble shooting and successful execution of complex experimental protocols for cell line development and technology assessment. The selected candidate will be developed to serve as a technical lead and functional area representative on project teams.



- PhD in Molecular Biology, Genetics, Biochemistry, or related Biological Sciences with at least 3 years of cell line development experience in industry.

- OR MS in Molecular Biology, Biochemistry, or related Biological Sciences with at least 6 years of cell line development experience in industry.

- OR BS in Molecular Biology, Biochemistry, or related Biological Sciences with at least 10 years of cell line development experience in industry.


- Experienced in developing cell line development for protein expression.

- Experienced in coordinate CLD responsibilities for pipeline project and ensure timely communication between CLD and other functional areas within CMC team.

- Excellent project leadership skills in driving for results and innovation. Strong communication and interpersonal skills to work in team environment.

- Deep knowledge in molecular biology and mammalian cell cultures.

- Experienced in vector construction.

- Experienced in IND filing and relevant documentation.

- Excellent oral and written communication skills


- Experienced in FACS sorting cell line development.

- Experienced in cell bank characterization.

- Experienced in automation and liquid handling equipment.

- Expertise of database and statistical software (e.g. Excel, JMP)

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.

If you need an accommodation for the application process please email us at

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Job: Preclinical Dev Generic

Job Title:Assoc Prin. Scientist, Preclinical Dev.

Primary Location: NA-US-NJ-Kenilworth

Employee Status: Regular

Number of Openings: 1

Hazardous Materials: DMSO, Phenol, Bacterial

Company Trade Name:Merck

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