PhD Studentship: Paper-Based Microfluidic Devices for Saliva Analysis

Location
United Kingdom
Posted
Dec 20, 2017
Closes
Mar 20, 2018
Organization Type
University and College
Hours
Full Time
Details

The analysis of saliva constituents at point-of-care settings can enable early diagnosis of metabolic and genetic disorders, low-cost screening, and surveillance of at-risk subjects. However, current minimally-invasive rapid saliva analysis systems for point-of-care settings have been limited in quantitative and differential diagnostics.

The aim of this project is to demonstrate a portable microfluidic system that allows quantitative analysis of biomarkers in saliva for point-of-care settings. The microfluidic system will consist of a capillary tube for sample collection, a reservoir for sample dilution, and a paper-based microfluidic device for biomarker analysis. The sensing regions will be functionalised with fluorescent crown ethers, o-acetanisidide, and seminaphtorhodafluor that are sensitive to mono- and divalent electrolytes, and their fluorescence outputs will be measured with a smartphone readout device.

The successful student will form part of a multidisciplinary team and will be supervised by Dr. Ali K. Yetisen based in the Institute of Translational Medicine (www.itmbirmingham.co.uk) and the School of Chemical Engineering at the University of Birmingham.

 

Funding Notes

Students must have an undergraduate degree or master’s degree in engineering, chemistry, physics, materials science or a closely related subject.

University of Birmingham scholarships are available for exceptional UK/EU students. Self-funded international students are welcome to apply this post. Potential candidates should contact Dr. Ali K. Yetisen (a.k.yetisen@bham.ac.uk) and include a CV. Applications will be evaluated on an on-going basis until the position is filled.

 

References

  • Paper-Based Microfluidic System for Tear Electrolyte Analysis. Lab on a Chip. 17, 1137-1148 (2017)
  • Paper-Based Microfluidic Point-of-Care Diagnostic Devices. Lab on a Chip, 13 (12), 2210-2251 (2013)

 

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