PhD Studentship: Paper-Based Microfluidic Devices: demonstrating a portable microfluidic system tha

United Kingdom
Dec 20, 2017
Mar 20, 2018
Organization Type
University and College
Full Time

The analysis of tear constituents at point-of-care settings has a potential for early diagnosis of ocular disorders such as eye diseases, low-cost screening, and surveillance of at-risk subjects. However, current minimally-invasive rapid tear analysis systems for point-of-care settings have been limited to the assessment of osmolarity or inflammatory markers and they cannot differentiate between dry eye subclassifications.

The aim of this project is to demonstrate a portable microfluidic system that allows quantitative analysis of biomarkers in the tear fluid that is suited for point-of-care settings. The microfluidic system will consist of a capillary tube for sample collection, a reservoir for sample dilution, and a paper-based microfluidic device for electrolyte analysis. The sensing regions will be functionalised with fluorescent crown ethers, o-acetanisidide, and seminaphtorhodafluor that are sensitive to mono- and divalent electrolytes, and their fluorescence emissions will be measured with a smartphone camera readout device.

The successful student will form part of a multidisciplinary team and will be supervised by Dr. Ali K. Yetisen based in the Institute of Translational Medicine ( and the School of Chemical Engineering at the University of Birmingham.


Funding Notes

Students must have an undergraduate degree or master’s degree in engineering, chemistry, physics, materials science or a closely related subject.

University of Birmingham scholarships are available for exceptional UK/EU students. Self-funded international students are welcome to apply this post. Applications will be evaluated on an on-going basis until the position is filled.



  • Paper-Based Microfluidic System for Tear Electrolyte Analysis. Lab on a Chip. 17, 1137-1148 (2017)
  • Paper-Based Microfluidic Point-of-Care Diagnostic Devices. Lab on a Chip, 13 (12), 2210-2251 (2013)


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