PhD Studentship: Dissecting the molecular pathways linking ribosome biogenesis, the nucleolar stres
Ribosome biogenesis is inextricably linked to cell growth and proliferation and uncontrolled cell growth is associated with increased levels of ribosome biogenesis. Further, It is emerging that the site of ribosome assembly, the nucleolus, acts as a key stress sensor, where many cellular stresses converge and act to trigger p53 stabilization resulting in growth arrest, apoptosis or cellular senescence. Multiple studies have suggested a link between ribosome biogenesis, cell transformation and the nucleolar stress response. However, the molecular mechanisms linking and regulating these processes remains largely uncharacterized. One factor that appears to connect these pathways is GLTSCR2 which has been shown to be directly involved in ribosome biogenesis and the nucleolar stress response. This project will investigate the overlapping roles that GLTSCR2 plays by dissecting the molecular interactions within each process to allow its disruption within one pathway, effectively uncoupling it from the other. This will be achieved using a combination of molecular biology techniques and subsequent in vivo analysis in embryonic stem cells.
The successful candidate will join a young and dynamic lab located within the highly collaborative environment of the Molecular biology and biotechnology department at the University of Sheffield. Candidates are expected to have, or about to obtain, an upper second class undergraduate degree in molecular biology, biochemistry or a related subject area. A Masters qualification in a similar area and relevant practical experience would be a distinct advantage.
- Full tuition fees (UK and EU).
- Annual, tax-free maintenance stipend at the standard RCUK rate (2016/17 is £14,296).
- Research Training Support Grant to cover international travel, secondments and exchanges.
These scholarships fund up to 3.5 years full-time study, subject to satisfactory progress.