PhD Studentship: Deciphering the molecular mechanism of action of the E3 complexes

Jan 19, 2018
Feb 28, 2018
Organization Type
University and College
Full Time
Position in the project: PhD student

Scientific discipline: genetics/biochemistry/structural biology/cryo-EM

Job type (employment contract/stipend): stipend

Position starts on: March 1st, 2018

Maximum period of contract/stipend agreement: 36 months
Institution : Laboratory of Protein Metabolism in Development and Aging (Wojciech Pokrzywa); Laboratory of Protein Structure (Marcin Nowotny), International Institute of Molecular and Cell Biology (IIMCB) in Warsaw

Project leaders: Dr. Wojciech Pokrzywa, Dr. Marcin Nowotny

Project title: Deciphering the molecular mechanism of action of the E3 complexes


Project description

The project combines genetics, biochemistry molecular and structural biology. It aims to determine the mechanism of action of ubiquitin ligases involved in protein homeostasis. It is a joint project of Dr. Marcin Nowotny (structural biology) and Dr. Wojciech Pokrzywa (genetics, biochemistry).

Key responsibilities include

The production of protein using different expression systems, purification of proteins, biochemical studies and structure determination by crystallography and cryo-EM. Additionally, worm genetics will be used in the project.


Profile of candidates/requirements

  1. Solid knowledge and documented laboratory experience in at least one of the following disciplines: structural biology, molecular biology, biochemistry, genetics
  2. Very good command of English (oral and written)
  3. Motivation and passion for experimental work


Required documents

  1. Motivation letter (in English).
  2. CV (in English)
  3. Subjects studied and grades obtained (in English or in Polish)
  4. Contact details of the scientific supervisor and if available other personal referees


Application deadline: 28.02.2018

For more details about the position please visit:,,

Please include in your offer:

“I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”

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