PhD Studentship: TAPAS: TArgeting Platelet Adhesion receptors in thrombosiS - Innovative methods to
The TAPAS, European Joint Doctorate (EJD), Innovative Training Network, funded by the European Commission under the H2020 research programme, is seeking an Early Stage Researcher (ESR) to undertake a PhD in:
Innovative methods to study proteomic signatures of glycoprotein receptor signaling
TAPAS is highly intersectoral and multi-disciplinary programme of work which will tackle the problem of thrombosis (blood clots) which can lead to heart attack and stroke and contributes to an estimated 40% of cardiovascular deaths in the EU, and over €200 billion a year to the EU economy. Current therapy in the prevention of arterial thrombotic events includes drugs that suppress the function of a specialised blood cell called a platelet. Platelets are necessary for preventing bleeding, but their unregulated or inappropriate activation can lead to thrombosis. Whilst suppressing platelet function is effective in a large proportion of patients, it is not perfect and some patients experience further thrombotic episodes, bleeding problems or even death.
The research will combine innovative approaches and develop new expertise to identify, understand and test new targets on blood platelets for the selective prevention and treatment of thrombotic diseases.
Host: Leibniz-Institut Fur Analytische Wissenschaften-ISAS, Germany
Supervisory team: Albert Sickmann (ISAS); Johan Heemskerk and Hugo ten Cate (Maastricht University); Angel Garcia (University of Santiago de Compostela)
Project locations: ISAS, Dortmund, Germany (Year 1 & 3), Maastricht University, The Netherlands (Year 1 & 2), University of Santiago de Compostela, Spain (Year 3)
Joint PhD Degree: Maastricht University and University of Santiago
This PhD will require the ESR to split their time between institutions and be mobile across the network. As part of the ITN network, you will have access to the various training activities organized by the network and to secondments at partner institutions.
For further information please see the TAPAS website: https://more.bham.ac.uk/tapas/
Apply here: https://more.bham.ac.uk/tapas/vacancies/
Project details: The project aims to develop novel techniques to study the role of glycoprotein receptor clustering in thrombosis. In Dortmund, the project starts to establish skillful application of innovative chemical crosslinking to detect receptor clustering and direct interaction proteins. The proteomics data will enable to get a big picture into glycoprotein receptors topology and stoichiometry of larger protein assemblies, provide information about low affinity binders and gain insight into role of posttranslational modification in glycoprotein receptor clustering and signaling. In Maastricht the application of custom build microfluidic device will shed light on the kinetics of the platelet signaling processes along their functional responses during the modulation of receptor clustering. In Santiago de Compostela this technology will be used to develop further functional and signalling studies, and analyse how they are altered by novel biologics and small molecule inhibitors. The scientific outcome will determine how novel biologics and small molecule inhibitors affect receptor clustering in platelets and contribute to a therapeutic approach of thrombosis.
Desirable student skills: strong chemistry with biochemistry skills, crosslinking experience
Living Allowance: This refers to the basic, gross amount for the benefit of the researcher to be paid to the researcher in monthly instalments. For this MSCA call launched in 2016-2017, the amount for an ESR is €3,110 per month (€37,320/year – 100%). This amount is then adjusted through the application of a country correction coefficient to the living allowance of the country in which the researcher will be recruited.* The final amount will not change in case of secondments to another beneficiary or partner organisation.
Mobility Allowance: All eligible researchers recruited within an ITN are entitled to receive this allowance. It contributes to the mobility related expenses of the researcher. The amount of the mobility allowance for the calls 2016-2017 amounts to €600 per month.
Family Allowance: A family allowance of €500 per month will be paid should the researcher have family, regardless of whether the family will move with the researcher or not.
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 766118.
ITN Mobility Rule: You must not have resided or carried out your main activity in the host country for more than 12 months in the last 3 years. Compulsory national service and/or short stays such as holidays are not taken into account.
Early-Stage Researcher: You shall be in the first four years (full-time equivalent research experience) of your research career and must not yet have been awarded a doctoral degree.
Reference: Beck F, Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition. Blood. 2017;129:e1-e12.
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