Research Associate / Senior Research Associate in a MRC funded project to determine the molecular m
- Employer
- Global Academy Jobs
- Location
- United Kingdom
- Closing date
- Apr 17, 2018
View more
- Sector
- Science, Life Sciences, Cell and Molecular Biology, Chemistry, Biochemistry
- Hours
- Full Time
- Organization Type
- University and College
- Jobseeker Type
- Academic (e.g. 'Lecturer')
Job Details
The project will utilise our recently developed immortalised erythroid line BEL-A that recapitulates erythropoiesis, along with CRISPR genome editing to create a cellular model system of this disease. The cells will be used along with comparative proteomics to obtain a comprehensive map of the repertoire of proteins aberrantly expressed in disease cells and techniques such as ChIPseq and Capture-C 3C to determine the mechanism by which the mutation results in disrupted gene regulation.
The position is open to candidates who have a PhD in Biochemistry, Cell Biology or related discipline. Experience of designing components for and performing CRISPR-Cas9 genome editing via NHEJ and HDR, of ChIP-seq and of cell culture for both cell lines and primary cells is essential
For informal enquiries, please contact Dr Jan Frayne, Jan.Frayne@Bristol.ac.uk, Tel: 0117 3312127.
Interviews are expecting to take place either during the week beginning 23rd or 30th April 2018.
The closing date for applications is 23:59 on 17 April 2018
The University is committed to creating and sustaining a fully inclusive culture. We welcome applicants from all backgrounds and communities.
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