2x Research Fellow in Synthetic Chemistry

We are seeking two Research Fellows in Synthetic Chemistry to join a major 3-year EPSRC-funded programme (awarded to Professors Steve Marsden and Adam Nelson) focused on developing new chemo- and biocatalytic tools for the direct elaboration of 3D fragment ‘hits’ into lead compounds.

You will assist the Investigators in delivering a general toolkit of methods for the direct functionalization of sp3 C-H bonds with medicinally-relevant functionality and applying this to the regio- and stereoselective elaboration of 3D fragments, exemplified in the context of fragments binding to disease-relevant proteins. You will have a PhD in synthetic chemistry methodology, catalysis development and/or synthetic biocatalysis (or will have submitted your thesis before the start date of the role), experience in the use of modern spectroscopic methods (e.g. two-dimensional NMR, IR, mass spectrometry) to characterise synthetic intermediates and a strong commitment to developing new chemical approaches to drive future drug and chemical probe discovery.