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Postdoctoral Position in Biological Chemistry/Biochemistry/Proteomics

Employer
Global Academy Jobs
Location
France
Closing date
Sep 21, 2018

Job Details

Project title: Activity-based protein profiling of the in vivo targets of a plasmodione analogue blocking the transmission of the human malaria parasite to mosquitoes. (Acronym: plasmoClick)

 

Job Summary

A 18 month post-doctoral position is open at the ECPM (University of Strasbourg) to use activity-based protein profiling (ABPP)-based probes to evaluate the metabolism of antimalarial plasmodione derivatives and fish the drug targets in the malaria parasite. To circumvent the enhanced transmission of drug resistant parasites to mosquitoes the team of the coordinator has developed an optimized plasmodione analogue with potent anti-gametocyte V in vitro and blocking-transmission properties in vivo. The postdoc project will use photoreactive plasmodione-derived alkynes as partners of the click reaction to fish and reveal target-protein adducts in mature P. falciparum rings and gametocytes upon irradiation and analyze them by mass spectrometry in chemical proteomics studies.

 

Job Description

The “Laboratoire d'Innovation Moléculaire et Applications (LIMA)” (UMR7042 / CNRS-Unistra-UHA), located in the “European School of Chemistry, Polymers and Materials (ECPM)” in Strasbourg and in Mulhouse, is looking for a candidate interested in a 18 month postdoctoral position (funded by Unistra IDEX) to undertake research at the Biological Chemistry/Biochemistry/Proteomics interface. This 18 months project will be supervised by Dr. Elisabeth Davioud-Charvet, scientific coordinator, within the consortium built on leading teams in biological chemistry of redox-active antiparasitic compounds (Dr. Elisabeth Davioud-Charvet, DR CNRS at LIMA-Strasbourg, & Marjorie Schmitt, CR CNRS, at LIMA-Mulhouse, UMR7042), mass spectrometry analysis & proteomics (Dr. Christine Schaeffer, IR CNRS IPHC, LSMBO, Strabourg), the biology of mosquitoes and malarial parasites (Dr Stephanie Blandin, CR INSERM, MIR / M3I, IBMC, Strasbourg), in the frame of a broad French-German scientific collaboration with a renowned German Biochemistry Institute (Prof. Katja Becker, University of Giessen, Germany).

The LIMA & LSMBO laboratories and the European School of Chemistry, Physics and Materials (ECPM) offer a stimulating research environment with ~ 60 scientists and possess a know-how in synthesis of functional molecules for materials, (bio)organic and medicinal chemistry, protein mass spectrometry & proteomics analysis. Expertise in proteomics analysis is available at LSMBO-IPHC, which is well equipped with a wide range of state-of-the-art mass spectrometers and chromatographic systems.

In the plasmoClick project new selective activity-based probes were designed for the identification of plasmodione protein targets. The postdoctoral researcher will undertake the analysis of the global interactome of this promising agent in asexual stages and in gametocytes using proteomics methodologies. Candidate targets will be validated with genetic engineering in Plasmodium.

We are looking for a highly motivated and ambitious candidate with a strong background in mass spectrometry analysis of proteins (fundamental criteria). Additional expertise in click chemistry and/or photoirradiation would be highly appreciated. The ideal candidate will have a proven track record of scientific excellence, very good communication and writing skills as well as a strong commitment to experimental work. The candidate should be also able to perform independent research, have good communicational and social skills and be eager to engage in collaborations with co-workers within this project. Knowledge of the French language is not required. Thorough knowledge of English, both oral and written is mandatory.

Company

Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

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