Research Fellow
- Employer
- Global Academy Jobs
- Location
- United Kingdom
- Closing date
- Aug 27, 2018
View more
- Sector
- Business and Finance, Science, Computer Science and IT, Social and Behavioral Sciences, Sociology
- Hours
- Full Time
- Organization Type
- University and College
- Jobseeker Type
- Academic (e.g. 'Lecturer')
Job Details
- Ph.D. and previous experience within the field of DNA damage signalling, DNA repair and/or DNA replication
- At least 1 first author publication in a high impact, peer-reviewed scientific journal
- Practical experience with in vitro mammalian cell (including making retrovirus and lentiviruses, generating stable cell lines)
- Practical experience with microscopy-based laboratory techniques (including immunofluorescence, chromosome breakage analysis)
- Practical experience with recombinant protein expression and purification, Western blotting and immunoprecipitation
- Practical experience with molecular biology (including primer design, RT-PCR, DNA/RNA isolation, cloning, DNA sequencing, expression plasmid generation, CRISPR technology)
- Practical experience with DNA and siRNA transfection
- Practical experience with DNA fibre analysis/DNA combing
- Effective interpersonal and communication skills (including written and presentational)
- The ability to work and think independently and to contribute to the planning of a programme of scientific research
- Effective organisational skills and the ability to prioritise work to meet deadlines
- Evidence of an ability to write to a standard required for research reports/publications
- Willingness to work flexibly, when necessary, to fulfil the needs of the research project
- Evidence of an ability to work individually and in a research team
- Working knowledge of Health and Safety requirements within the laboratory setting
- Familiarity with computer packages for data analysis
- The ability and willingness to keep up with and have a working knowledge of the scientific literature in the field of the project
- High level analytical capability
- Ability to communicate complex information clearly
Applications are invited for a highly motivated and organised post-doctoral research fellow to join the Stewart laboratory, based at the University of Birmingham, to work on understanding how inherited deficiencies in components of the DNA damage response, particularly proteins involved in DNA repair and/or DNA replication, contribute to the development of human disease (for examples see: Ogiet al (2012) PLoS Genet 8:e1002945; Murrayet al (2015) Am J Hum Genet 96:412-24; Harley et al (2016) Nat Genet 48:36-43; Byrdet al (2016) PLoS Genet 12:e1005945).
Ongoing research projects within the laboratory focus on characterising the impact of patient-associated mutations in known DNA repair/replication genes on genome stability, the identification of novel human disease genes associated with defective DNA repair/replication and identifying roles for previously uncharacterised genes/proteins in the DNA damage response (for example: Higgs et al (2015) Mol Cell 59:462-77; Higgs et al (2018) Mol Cell Epub).
Candidates will be expected to undertake novel, cutting-edge, laboratory-based research within the field of the DNA damage response and replication, specified within a CR-UK funded research programme.
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