PostDoc - Development of Hybrid Organic-Inorganic Solids for Hyperpolarized Magnetic Resonance
- Employer
- Global Academy Jobs
- Location
- France
- Closing date
- Oct 31, 2018
View more
- Sector
- Science, Chemistry, Biochemistry
- Hours
- Full Time
- Organization Type
- University and College
- Jobseeker Type
- Academic (e.g. 'Lecturer')
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Job Details
The aim of this project is the development of innovative porous silica-based materials containing organic stable radicals (TEMPO units) using sol-gel techniques. This project will be performed in the frame of o collaboration between the C2P2 laboratory and the CRMN in Lyon. This project already led to very promising results published in high ranked journals (PNAS, ACIE, Nature Communications).
The first generation of silica matrices allowed to yield pure solutions of ‘hyperpolarized' tracers that are promising as contrast agents for in-vivo MRI experimentssuch as the real-time in-vivodetection of cancer tumours. Using this technique, cancerous regions that were invisible to standard MRI techniques could be identified without ionizing radiations and without any false positives.
To reach this goal, new silica matrices need to be developed to ensure long live hyperpolarization state of the tracers as so far hyperpolarized samples are only very short lived (typically 1 minute) which prevents their widespread use.
In this context, we are looking for a post-doctoral researcher to work on a newgeneration of materialsto extend the lifetime of these ‘hyperpolarized' MRI tracers to days (doi:10.1038/ncomms13975) which will potentially lead to a radical democratization of the method. Your project will be at the interface between organic and material chemistry, and will involvethe design, synthesis, characterization, and testing of novel porous materialsbased on hybrid organic-inorganic silicas. The successful candidate will evolve in a very interdisciplinary environment, and interact with chemists, biologists and physicists. You may for example participate in the in-vivohyperpolarized MRI experiments, or pursue applications in the field of drug discovery or metabolomics.
The first generation of silica matrices allowed to yield pure solutions of ‘hyperpolarized' tracers that are promising as contrast agents for in-vivo MRI experimentssuch as the real-time in-vivodetection of cancer tumours. Using this technique, cancerous regions that were invisible to standard MRI techniques could be identified without ionizing radiations and without any false positives.
To reach this goal, new silica matrices need to be developed to ensure long live hyperpolarization state of the tracers as so far hyperpolarized samples are only very short lived (typically 1 minute) which prevents their widespread use.
In this context, we are looking for a post-doctoral researcher to work on a newgeneration of materialsto extend the lifetime of these ‘hyperpolarized' MRI tracers to days (doi:10.1038/ncomms13975) which will potentially lead to a radical democratization of the method. Your project will be at the interface between organic and material chemistry, and will involvethe design, synthesis, characterization, and testing of novel porous materialsbased on hybrid organic-inorganic silicas. The successful candidate will evolve in a very interdisciplinary environment, and interact with chemists, biologists and physicists. You may for example participate in the in-vivohyperpolarized MRI experiments, or pursue applications in the field of drug discovery or metabolomics.
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