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Postdoctoral Research Fellow in Single- Molecule Optics/Biophysics Applied to Membrane Receptors&#1

Employer
Global Academy Jobs
Location
United Kingdom
Closing date
Feb 15, 2019

Job Details

Job Purpose

We are seeking a highly motivated physical scientist with relevant expertise in single-molecule microscopy and the design and construction of advanced optical systems to join our vibrant, multidisciplinary team at the Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham (UK). The postdoctoral position is supported by a large research programme funded by the Wellcome Trust.

Our group based at IMSR/COMPARE investigates the molecular mechanisms of signalling by G protein-coupled receptors (GPCRs), which mediate the effects of many hormones and neurotransmitters and are major drug targets. To this end, we develop innovative biophysical methods based on single-molecule microscopy and FRET (e.g. Calebiro et al. PNAS 2013; Godbole et al. Nat. Commun. 2017; Sungkaworn et al. Nature 2017).

The successful candidate will be responsible for the design and development of new optical systems and approaches based on TIRF and advanced PSF engineering for ultrafast, multicolour single-particle tracking in 3D and single-molecule FRET. He/she will use these innovative approaches to study the conformational dynamics, diffusion and functional organization of GPCRs both in vitro with purified proteins and in living cells.

The job holder will be expected to develop research objectives and proposals for their own or joint research, with assistance of a mentor if required; they will collect research data, analyse and interpret the data and then disseminate research findings for publication, research seminars etc.They will also contribute to writing bids for research funding.

 

Person Specification

  • Hold a bachelor and/or master degree in physics, biophysics, engineering or equivalent field
  • Completed or about to complete a PhD in single-molecule microscopy/FRET, innovative experimental optics or related area
  • Solid background in single-molecule imaging or similar advanced microscopy methods
  • proven record in the design and use of advanced optical systems for biological applications
  • Good knowledge of scientific software and programming languages (Matlab, LabVIEW, etc.) is required.
  • Enthusiasm for interdisciplinary experimental research and team work
  • Drive to learn new skills
  • High level analytical capability
  • Ability to communicate complex information clearly
  • Ability to assess resource requirements and use resources effectively

 

Company

Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."

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