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2-year postdoctoral position at Universitätsspital, Basel.

Employer
Global Academy Jobs
Location
Switzerland
Closing date
Jan 11, 2019

Job Details

Skeletal muscle wasting is a debilitating disease that is due to the imbalance in protein synthesis and degradation, compromises patient mobility and survival. In the past few years we have established cutting-edge experimental techniques for the identification of the molecular regulators that control protein synthesis and degradation in human myofibers under atrophic stress. In this project we aim to use these methodologies to identify targetable regulators of muscle growth to counteract the muscle disease.

 

Your position

The successful applicant will drive the project. He/she will establish and characterize clonal human myoblast populations engineered with CRISPR-Cas9 mediated gene editing to obtain the model system for the project. He/she will apply systems, biology approaches including RNA-seq, ribosome footprint sequencing, and proximity dependent labeling (BioID2) coupled MS/MS to understand the dysregulation between protein synthesis and degradation upon atrophy.

Your profile

The applicant should hold a PhD degree in life sciences and have a strong background in cellular biology, molecular biology and biochemistry. Knowledge of next generation sequencing techniques will be a plus. We are looking for highly motivated, dedicated candidate with good teamworking skills, who is interested in muscle physiology and systems biology.

We offer you

We offer state-of-the art infrastructure, a maximum of 2 years funding (starting beginning of 2019) by the FSRMM (Fondation Suisse de Recherche sur les Maladies Musculaires) at a standard postdoc salary level as published by the Swiss National Science Foundation. We provide excellent support and supervision by senior scientists with extensive expertise in neuromuscular diseases, systems biology and mechanisms of regulating gene expression (Dr. Lionel Tintignac from Prof. M. Sinnreich's group (Department of Biomedicine) and Dr. Nitish Mittal from Prof. M. Zavolan (Biozentrum)).

Application / Contact

Applications (CV, motivation letter and contact of two references) should be submitted via e-mail by February 15 to lionel.tintignac@unibas.ch; nitish.mittal@unibas.ch

Company

Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."

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