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Postdoc in Human Molecular Genetics

Employer
Global Academy Jobs
Location
Poland
Closing date
Mar 20, 2019

Job Details

The Position of Assistance Professor is available in Department of Gene Expression of Adam Mickiewicz University which is the largest institution of higher education in Poznan and one of the largest and best institutions of higher education in Poland.

 

Scientific discipline:

Biology, biotechnology, biochemistry, medicine

 

Salary:

5 000 PLN per month (about 1 300 USD) + health insurance. No housing or transportation will be provided. Relocation assistance for this position is not available.

 

Responsibilities

A highly motivated researcher is sought to join the human molecular genetic research team under the supervision of Prof. UAM dr hab. Krzysztof Sobczak. We focus on studying the molecular pathomechanism and experimental therapy of hereditary neuro-muscular disease, myotonic dystrophy.

Myotonic dystrophy type 1 (DM1) is an RNA dominant disorder caused by expansion of a CTG repeat in the 3'-UTR of the DMPK gene. The DMPK transcripts containing highly expanded CUG repeats (CUGexp) are retained in the nucleus in discrete foci. Their nuclear retention is partly a function of the interaction of CUGexp RNA with poly(CUG) binding proteins, such as, splicing factors in the Muscleblind-like (MBNL) family. The pathogenic effects of CUGexp RNA are due in part to sequestration of MBNL proteins, which results in misregulated alternative splicing that these proteins normally regulate.

In our research we focus on deeper understanding of some aspects of molecular pathomechanism of DM, especially associated with miRNA metabolism and MBNL function, as well as application of antisense oligomers to disrupt pathogenic interaction of CUGexp with protein in vivo.

A broad range of experimental methods are employed, including microarray hybridization, next generation sequencing, fluorescence in situ hybridization; DNA/RNA purification, cloning, genotyping, sequencing and hybridization; protein immunoblots, immunoprecipitation, and immunohistochemistry; tissue culture, transfection and transduction of cells, and experiments with mouse models.

Please include in your offer: ‘'I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation)''.

Company

Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."

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