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Postdoctoral position in molecular and structural biology

Employer
Global Academy Jobs
Location
France
Closing date
Feb 22, 2019

Job Details

The approaches used will be based on the use of cell-free translation extracts that will allow to first assemble and then purify translation initiation complexes on our model messenger RNAs. The composition of these complexes will be determined by mass spectrometry and their structure by advanced structural approaches. The techniques used will be:
  • Biochemistry and molecular biology methods dedicated to the study of proteins and nucleic acids
  • Preparation of cell-free extracts for in vitro translation, purification of ribonucleic complexes suitable for structural studies by crystallography / cryo-electron microscopy
  • Crystallography and / or cryo-electron microscopy
  • Analysis of electronic density maps
  • Modeling the atomic structures of proteins / nucleic acids within complexes

The candidate will have to develop his project autonomously and will participate in the supervision of students and technical staff.

The team 'Evolution of translation initiation systems in eukaryotes' of the 'Architecture et Réactivité de l'ARN' unit (UPR 9002 CNRS) of the Institute of Molecular and Cell Biology of Strasbourg, is recruiting a Post-doctoral researcher for the study of structure-function relationships of ribonucleic complexes during the translation initiation step in higher eukaryotes. The project will consist in characterizing structurally and functionally macromolecular complexes allowing the initiation of the translation of model messenger RNAs.

The candidate will integrate a team of biochemistry and molecular biology. The implementation of the structural part of this project will be based mainly on the skills of the candidate who will carry out this project independently.

Strong expertise in structural biology (Crystallography / Cryo-Electron Microscopy) on macromolecular complexes containing the ribosome is required. This includes mastering biochemistry and molecular biology approaches for complex purification. The candidate should also be able to interpret electronic density maps to establish atomic models of ribonucleic complexes containing the ribosome. Applicants who have demonstrated their ability to write grant applications will be given priority.

Applications will only be made via the recruitment website

Company

Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.

"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."

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