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Research Fellow in Molecular Virology

Employer
Global Academy Jobs
Location
United Kingdom
Closing date
Mar 13, 2019

Job Details

Are you an ambitious researcher looking for your next challenge?

Do you have an established background in molecular virology Do you want to further your career in one of the UKs leading research intensive Universities?

 

This project involves the study of aspects of the replication of foot-and-mouth disease virus (FMDV) and will be based in the picornavirus laboratories led by Professors Nicola Stonehouse and David Rowlands. Picornaviruses are responsible for a number of serious diseases, including polio, FMD and some emerging diseases, e.g. human hand, foot and mouth disease. There is an urgent need to develop new therapeutic strategies to address the continuing issue of picornavirus infection. Genome replication, a key therapeutic target, is usually sequestered within ‘replication complexes', thought to improve efficiency and protect this vulnerable part of the lifecycle. However, for picornaviruses, these are poorly defined. We have recently established a reciprocal complementation system to study the ‘cross talk' between FMDV genomes Herod et al, 2015,2016,2017. These studies have highlighted the importance of multiple co-infection in viral replication. We will exploit this system here. The project employs replicons - mini-genomes that allow the study of replication in a safe virus-free way, which is highly convenient for the study of the mechanics of genome replication. Using reciprocal complementation (together with state-of-the art imaging and structural techniques available in-house) we aim to dissect the functions of both the RNA and protein components of replication complex. i.e. Identifying novel roles of the essential FMDV non-structural proteins and precursors in replication, focusing on the polymerase (3D) and primer of replication (VPg) using mutagenesis and replication inhibitors.Investigating the development and structure of sites of replication (replication factories) in a time-resolved manner e.g. by PALM/STORM and EM. You should have a PhD (or close to completion) in Virology, Cell Biology, Molecular Biology or a closely allied discipline. A strong background in virology and/or molecular biology with practical experience in recombinant DNA technologies is essential.

To explore the post further or for any queries you may have, please contact: Professor Nicola Stonehouse, Professor in Molecular Biology Tel: +44 (0)113 343 3102; email: N.J.Stonehouse@leeds.ac.uk

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