PhD Research Project - Magnetic Nanoparticles for biomedical applications
- Employer
- Global Academy Jobs
- Location
- France
- Closing date
- May 13, 2019
View more
- Sector
- Science, Life Sciences, Cell and Molecular Biology, Physical Sciences and Engineering, Physics, Chemistry, Biochemistry
- Hours
- Full Time
- Organization Type
- University and College
- Jobseeker Type
- Academic (e.g. 'Lecturer')
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Job Details
Recruitment of a PhD student at Sorbonne Université, in the PHENIX laboratory
Magnetic nanoparticles with shape anisotropy: Synthesis, characterization and study of their cellular internalization pathways for biomedical applications
The PHENIX laboratory (team Colloïdes INorganiques) at Sorbonne Université seeks a PhD candidate to work in the field of magnetic nanoparticles for biomedical applications. The research project will start on October 1st 2019. The PhD student will be supervised by Dr J.-M. Siaugue and Dr E. Secret.
Research project and objectives:
Magnetic nanoparticles anisotropic in shape (such as nanorods) present several advantages compared to spherical ones, especially regarding biomedical applications. The aim of this PhD project is to evaluate the impact of the shape, the size and the surface functionalization of iron oxide magnetic nanorods on their magnetic properties and their cellular internalization pathways. To this end, the first research axis will be the optimization of a simple and robust protocol for the synthesis of magnetic nanorods, with a controlled composition and a large range of diameters and lengths. The cellular internalization pathways of these nanorods will then be studied, to assess their capacity to avoid an endosomal entrapment when entering cells. The best candidates, which will avoid the endosomal entrapment, will then be thoroughly studied for biomedical applications such as MRI or magnetic hyperthermia treatment of cancer.
This project is thus at the interface between material chemistry (nanorods synthesis and functionalization), physics (magnetic properties, MRI, magnetic hyperthermia) and biology (cellular internalization, cytotoxicity, in vitro magnetic hyperthermia).
Host laboratory and infrastructures
The CIN (Colloïdes INorganiques) team of the PHENIX lab is internationally recognized in the field of magnetic nanoparticles. The lab is fully equipped for the synthesis and the characterization of the magnetic nanorods. It recently invested in an all new cell culture lab, where all the cell biology work will be done.
Magnetic nanoparticles with shape anisotropy: Synthesis, characterization and study of their cellular internalization pathways for biomedical applications
The PHENIX laboratory (team Colloïdes INorganiques) at Sorbonne Université seeks a PhD candidate to work in the field of magnetic nanoparticles for biomedical applications. The research project will start on October 1st 2019. The PhD student will be supervised by Dr J.-M. Siaugue and Dr E. Secret.
Research project and objectives:
Magnetic nanoparticles anisotropic in shape (such as nanorods) present several advantages compared to spherical ones, especially regarding biomedical applications. The aim of this PhD project is to evaluate the impact of the shape, the size and the surface functionalization of iron oxide magnetic nanorods on their magnetic properties and their cellular internalization pathways. To this end, the first research axis will be the optimization of a simple and robust protocol for the synthesis of magnetic nanorods, with a controlled composition and a large range of diameters and lengths. The cellular internalization pathways of these nanorods will then be studied, to assess their capacity to avoid an endosomal entrapment when entering cells. The best candidates, which will avoid the endosomal entrapment, will then be thoroughly studied for biomedical applications such as MRI or magnetic hyperthermia treatment of cancer.
This project is thus at the interface between material chemistry (nanorods synthesis and functionalization), physics (magnetic properties, MRI, magnetic hyperthermia) and biology (cellular internalization, cytotoxicity, in vitro magnetic hyperthermia).
Host laboratory and infrastructures
The CIN (Colloïdes INorganiques) team of the PHENIX lab is internationally recognized in the field of magnetic nanoparticles. The lab is fully equipped for the synthesis and the characterization of the magnetic nanorods. It recently invested in an all new cell culture lab, where all the cell biology work will be done.
Company
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